Anti-hyperuricemic property of 6-shogaol via self-microemulsifying drug delivery system in model rats: Formulation design, in vitro and in vivo evaluation.

Anti-hyperuricemic property of 6-shogaol via self-microemulsifying drug delivery system in model rats: Formulation design, in vitro and in vivo evaluation. Drug Dev Ind Pharm. 2019 Apr 16;:1-42 Authors: Yang Q, Wang Q, Feng Y, Wei Q, Sun C, Firempong CK, Adu-Frimpong M, Li R, Bao R, Toreniyazov E, Ji H, Yu J, Xu X Abstract The prevalence of hyperuricemia is relatively high worldwide, and a great number of patients are suffering from its complications. 6-shogaol, an alkylphenol compound purified from the root of ginger (Zingiber officinale Roscoe), has been proved to possess the diverse pharmacological activities. However, its poor aqueous solubility usually lead to low bioavailability, and further clinical applications will be greatly discounted. The current study aimed to formulate a 6-shogaol-loaded-Self Microemulsifying Drug Delivery System (SMEDDS) to amend low aqueous solubility and bioavailability orally as well as potentiate the hyperuricemic activity of the 6-shogaol. SMEDDS was developed with central composite design established on a two system components viz., 18.62% W/W ethyl oleate (oil phase) and ratio of tween 80 (surfactant) to PEG 400 (co-surfactant) (1.73:1, W/W). Based on quadratic model, the navigation of the design space could generate spherically-shaped and homogenous droplets with respective mean particle diameter, polydispersity and of 20.00 ± 0.26 nm and 0.18 ± 0.02. The 6-shogaol-SMEDDS showed sig...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research