Pellino1 specifically binds to phospho-Thr18 of p53 and is recruited to sites of DNA damage.

This study provides evidence that Pellino1 translocates to damaged DNA in the nucleus and has a functional role in p53 signaling and the DNA damage response.
PMID: 30987826 [PubMed - as supplied by publisher]

Source: Biochemical and Biophysical Research communications - April 11, 2019 Category: Biochemistry Authors: Dai L, Lin J, Said AB, Yau YH, Shochat SG, Ruiz-Carrillo D, Sun K, Chandrasekaran R, Sze SK, Lescar J, Cheung PC Tags: Biochem Biophys Res Commun Source Type: research