Adipocyte alterations in endometriosis: reduced numbers of stem cells and microRNA induced alterations in adipocyte metabolic gene expression.

CONCLUSIONS: We demonstrate that microRNAs Let-7b and miR-342-3p affected metabolic gene expression significantly in adipocytes of women with endometriosis. Similarly, there is a reduction in the adipose stem cell population in a mouse model of endometriosis. Taken together these data suggest that endometriosis alters BMI in part through an effect on adipocytes and fat metabolism.
PMID: 30982470 [PubMed - in process]

Source: Reproductive Biology - April 14, 2019 Category: Reproduction Medicine Authors: Zolbin MM, Mamillapalli R, Nematian SE, Goetz L, Taylor HS Tags: Reprod Biol Endocrinol Source Type: research