Intravenously Injected Mesenchymal Stem Cells Penetrate the Brain and Treat Inflammation-Induced Brain Damage and Memory Impairment in Mice

Conclusions 1. Intravenously injected MSCs penetrate the brain of LPS-treated mice. 2. Either allogenic (mouse) or xenogeneic (human) MSCs prevent and reverse the pathogenic effect of LPS on the brain nAChRs, Aβ accumulation, mitochondria and memory impairment. 3. The MSCs therapeutic action is largely due to their humoral factors and is accompanied by activation of micro- and macroglia. Ethics Statement This study was carried out in accordance with the recommendation of the guidelines of the Animal Care and Use Committee of Palladin Institute of Biochemistry, Kiev. The protocol was approved by the IACUC of Palladin Institute of Biochemistry. Author Contributions MS, OD, SK, OL, and VKo made substantial contributions to the conception or design of the work. LK, OL, LV, KU, MS, NS, and AU contributed to acquisition, analysis, and interpretation of data for the work. MS drafted the work. OD, VKy, and AU revised it critically for important intellectual content. LK, OL, LV, KU, SK, VKo, OD, NS, VKy, and AU finally approved the version to be published. LK, OL, LV, KU, SK, VKo, OD, NS, VKy, and AU agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potentia...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research