Organocatalytic enantioselective direct alkylation of phloroglucinol derivatives: asymmetric total synthesis of (+)-aflatoxin B2.

Organocatalytic enantioselective direct alkylation of phloroglucinol derivatives: asymmetric total synthesis of (+)-aflatoxin B2.
Chem Commun (Camb). 2019 Apr 15;:
Authors: Wang Z, Zu L
Abstract
The organocatalytic enantioselective Friedel-Crafts alkylation of phloroglucinol derivatives with enals is reported, providing general access to the benzylic chiral centers shown in a variety of phloroglucinol natural products. The synthetic utility is demonstrated by the very concise asymmetric total synthesis of aflatoxins B2.
PMID: 30984932 [PubMed - as supplied by publisher]

Source: Chemical Communications - April 14, 2019 Category: Chemistry Authors: Wang Z, Zu L Tags: Chem Commun (Camb) Source Type: research