A 'sulfonyl-azide-free' (SAFE) aqueous-phase diazo transfer reaction for parallel and diversity-oriented synthesis.

A 'sulfonyl-azide-free' (SAFE) aqueous-phase diazo transfer reaction for parallel and diversity-oriented synthesis.
Chem Commun (Camb). 2019 Apr 15;:
Authors: Dar'in D, Kantin G, Krasavin M
Abstract
Diazo transfer reactions are notoriously associated with the use of potentially explosive sulfonyl azides. The first 'sulfonyl-azide-free' (SAFE) protocol for producing diazo compounds from their active-methylene precursors via the Regitz diazo transfer reaction was developed and has displayed a remarkable substrate scope. It can be applied to generating arrays of diazo compounds for further evolution via combinatorial chemistry and a range of scaffold-generating transformations.
PMID: 30985842 [PubMed - as supplied by publisher]

Source: Chemical Communications - April 14, 2019 Category: Chemistry Authors: Dar'in D, Kantin G, Krasavin M Tags: Chem Commun (Camb) Source Type: research