Size-controlled DNA-cross-linked hydrogel coated silica nanoparticles served as a ratiometric fluorescent probe for the detection of adenosine triphosphate in living cells.

Size-controlled DNA-cross-linked hydrogel coated silica nanoparticles served as a ratiometric fluorescent probe for the detection of adenosine triphosphate in living cells.
Chem Commun (Camb). 2019 Apr 16;:
Authors: Ji X, Wang J, Niu S, Ding C
Abstract
Herein, we have designed a ratiometric fluorescent nanoprobe for adenosine triphosphate sensing and imaging in living cells, based on silica nanoparticles and a DNA-functionalized hybrid hydrogel. This ratiometric detecting method could validly avoid false-positive signals. Due to its controllable size, favorable biocompatibility and biostability, the nanohydrogel exhibited high cellular permeability and fast response in living cells.
PMID: 30989156 [PubMed - as supplied by publisher]

Source: Chemical Communications - April 15, 2019 Category: Chemistry Authors: Ji X, Wang J, Niu S, Ding C Tags: Chem Commun (Camb) Source Type: research