Aryl and arylalkyl substituted 3-hydroxypyridin(1H)-2-ones: Synthesis and evaluation as inhibitors of influenza A endonuclease.

We report herein on the structure-activity relationships associated with various para-substituted 5-phenyl derivatives of 6-(p-fluorophenyl)-3-hydroxypyridin (1H)-2-one and the effect of using naphthyl, benzyl, and napthylmethyl groups as alternatives to the p-fluorophenyl substituent on their activity as endonuclease inhibitors.
PMID: 30983160 [PubMed - as supplied by publisher]

Source: ChemMedChem - April 13, 2019 Category: Chemistry Authors: LaVoie EJ, Sagong HY, Bauman JD, Nogales A, Martínez-Sobrido L, Arnold E Tags: ChemMedChem Source Type: research