Editorial: Nano- and Microparticle-Induced Cell Death, Inflammation and Immune Responses

Editorial: Nano- and Microparticle-Induced Cell Death, Inflammation and Immune Responses Shrikant R. Mulay1,2†, Martin Herrmann3†, Rostyslav Bilyy3,4†, Alexander Gabibov5† and Hans-Joachim Anders1*† 1Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany 2Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow, India 3Department of Internal Medicine 3, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany 4Department of Cytology Histology and Embryology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine 5M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia Editorial on the Research Topic Nano- and Microparticle-Induced Cell Death, Inflammation and Immune Responses Introduction Crystals, fibers, and other microparticles form inside the body from nutrients or metabolites but also enter the body from outside during environmental or occupational exposures. Altogether crystal and microparticle-related diseases account for numerous medical disorders (1). In some of these disorders, the crystal masses themselves cause the problem, e.g., when stones obstruct the bile ducts or the urinary draining system. In other crystal-immune responses largely account for clinical symptoms and tissue dama...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Re: Yang CJ, Kumar A, Gulack BC, Mulvihill MS, Hartwig MG, Wang X, et  al. Long-term outcomes after lobectomy for non–small cell lung cancer when unsuspected pN2 disease is found: A National Cancer Data Base analysis. J Thoracic Cardiovasc Surg. 2016;151:1380-8.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Notice of Correction Source Type: research
Authors: Ridruejo E, Garcia-Agudo R, Mendizabal M, Aoufi-Rabih S, Dixit V, Silva M, Fabrizi F Abstract BACKGROUND AND AIMS: The advent of direct-acting antiviral agents promises to change the management of hepatitis C virus infection (HCV) in patients with chronic kidney disease (CKD), a patient group in which the treatment of hepatitis C was historically challenging. We investigated the safety and efficacy of all-oral, interferon-free direct-acting antiviral agents for the treatment of hepatitis C in a 'real-world' cohort of patients with CKD. METHODS: We performed an observational single-arm multi-centre stud...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
Lactation is a unique period in which the maternal skeleton acts as a storehouse to provide substantial calcium to milk. Women who exclusively breastfeed lose an average of 210 mg of calcium per day, which doubles or triples with twins and triplets. Data from rodent and clinical studies are consistent with skeletal calcium being released to provide much of the calcium needed for milk production. This is programmed to occur independently of dietary calcium intake or intestinal calcium absorption, which remains at the prepregnant rate in breastfeeding women. After weaning, the skeleton is restored to its prior mineralization...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Gliomas account for approximately 80% of primary malignant tumors in the central nervous system. Despite aggressive therapy, the prognosis of patients remains extremely poor. Glioma stem cells (GSCs), considered a potential target of therapy for their crucial role in therapeutic resistance and tumor recurrence, are believed to be key factors in the disappointing outcome. Here, we took advantage of GSCs as the cell model to perform high-throughput drug screening, and the old antibiotic clofoctol was identified as the most effective compound, showing reduction of colony formation and induction of apoptosis of GSCs. Moreover,...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Lactation induces bone loss to provide sufficient calcium in the milk, a process that involves osteoclastic bone resorption but also osteocytes and perilacunar resorption. The exact mechanisms by which osteocytes contribute to bone loss remain elusive. Osteocytes express genes required in osteoclasts for bone resorption, including cathepsin K (Ctsk), and lactation elevates their expression. We show that Ctsk deletion in osteocytes prevented the increase in osteocyte lacunar area seen during lactation, as well as the effects of lactation to increase osteoclast numbers and decrease trabecular bone volume, cortical thickness,...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Dalton Trans., 2019, Accepted Manuscript DOI: 10.1039/C9DT01855G, PaperBitupon Borthakur, Ashwini Kumar Phukan Cyclic alkyl amino carbene (CAAC) anchored [FeFe] –hydrogenase model complex featuring rotated conformation at one of the iron centers is found to be promising candidate for effective production of dihydrogen. A... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
Analyst, 2019, Advance Article DOI: 10.1039/C9AN00691E, PaperBo Yin, Sha Sha Li, Shao Hua Lu, Jia Ying Mi, Hong Lin Zhai The feature information was extracted from the 3D spectrum by the TM method, and the simultaneous quantification of intracellular thiols was realized. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
AbstractA novel series of coumarin-pyridine/fused pyridine hybrids were designed and synthesized. Their anticancer activity was evaluated against human cancer cell lines MCF-7, HCT-116, HepG-2, and A549. Compounds9,10, and11 showed the most potent growth inhibitory activities with IC50 values ranging from 1.1 to 2.4  μM, against MCF-7 cell line. Flow cytometric analysis revealed that these compounds induced cell cycle arrest in the G2/M phase followed by apoptotic cell death. Consistent with these results, the activity of caspase-3 in MCF-7 cells was tested. The results indicated that compounds9,10, and11 increas...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
Archaeological dig will be first at building where thousands of Wellington ’s men were treatedA group of 25 British and Dutch military veterans are to join the first excavation of the main field hospital established by the Duke of Wellington during the Battle of Waterloo.The former soldiers, sailors and RAF personnel will work with archaeologists, led by Prof Tony Pollard of Glasgow University, to explore the farm buildings of Mont-St-Jean, where thousands of wounded soldiers received primitive first aid as shot and shell rained down on them.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Archaeology Military Post-traumatic stress disorder Belgium Netherlands Napoleon Bonaparte Science Mental health Society UK news Europe World news Source Type: news
(Medical College of Georgia at Augusta University) A checkpoint may delay travelers but it can help give cancer free rein by suppressing the natural immune response that should destroy it, researchers say.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
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