MicroRNAs as Molecular Switches in Macrophage Activation

Conclusions In the last decade, several efforts have been made to shed light into the molecular mechanisms driving the inflammatory response, in all its facets. miRNAs have been demonstrated to be pivotal players actively participating in the modulation of the early phase as well as the resolution of inflammation. Recent findings on their involvement in chronic inflammatory conditions, sepsis, and tumors strongly encourage the development of new miRNA-based therapeutic strategies. Author Contributions All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments Activities of the lab on microRNA biology has been supported by research grants from the European Community's Seventh Framework Program (FP7-2007-2013) under grant agreement HEALTH-F4-2011-281608 (TIMER), Ministero dell'Istruzione dell'Università e della Ricerca (PRIN project 2009JP9WTS_002; FIRB project RBFR08CW8G), and the Italian Association for Cancer Research (AIRC-IG #19213-2016). References 1. Mantovani A, Biswas SK, Galdiero MR, Sica A, Locati M. Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol. (2013) 229:176–85. doi: 10.1002/path.4133 P...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research