The Ins and Outs of Cerebral Malaria Pathogenesis: Immunopathology, Extracellular Vesicles, Immunometabolism, and Trained Immunity

Conclusion and Future Directions The ECM model has produced a wealth of information on CM pathogenesis in mice with the aim to find an adjunctive therapy for HCM but its validity has been questioned. However, several investigators have provided a critical and evidence-based defense of this model (17, 128–131) and from knowledge gained from it, numerous laboratories have tested preclinical therapeutic interventions. Many have demonstrated efficacy at blocking the development of ECM but disappointingly, in a majority of cases, this was only found when administered before or early post infection and prior to the onset of clinical neurological signs. Therefore, only a few can justify, as therapies, a large-scale evaluation in HCM. A rare case of efficacy of treatment even when administered after the onset of clinical signs in the ECM model is the injection of IMP (52). The only other studies to date having demonstrated treatment efficacy after the onset of ECM have targeted CD8+ T cell binding to endothelial cells, and finally, immunometabolism. These successes have renewed hopes that the mouse model of ECM will continue to bring novel ideas/concepts which then will need to be confirmed or infirmed in HCM. For example, the characterization of retinal pathology in ECM (132) and (133), which was followed by the demonstration of its usefulness in HCM (134–137) (and many others) or MRI findings of brain alterations, originally described in 2005 for ECM (97), and followed...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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CONCLUSION: Our study suggests the clinical efficiency of belimumab in a series of 7 patients presenting a resistant and progressive CLE. PMID: 31980188 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
CONCLUSION: We report a case of chronic enterovirus infection associating meningitis and myofasciitis in an adult with rituximab-induced hypogammaglobulinemia. Outcome was favorable under treatment with intravenous immunoglobulins. PMID: 31980187 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Publication date: Available online 25 January 2020Source: Biological ControlAuthor(s): G.A. McCulloch, E.V. Mauda, L.D. Chari, G.D. Martin, K. Gurdasani, L. Morin, G.H. Walter, S. RaghuAbstractLycium ferocissimum (African boxthorn) is one of the most troublesome weeds in Australia. Biological control may have potential to manage this weed, but taxonomic uncertainty needs to be addressed first to facilitate searches for potential agents. We sampled putative L. ferocissimum (i.e. tentatively identified morphologically in the field) across its native range in South Africa and introduced range in Australia. Morphometric and ge...
Source: Biological Control - Category: Biology Source Type: research
Publication date: April 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 188Author(s): Didem Cetin, Meltem Okan, Erhan Bat, Haluk KulahAbstractDetection of circulating tumor cells (CTCs) from the bloodstream holds great importance to diagnose cancer at early stages. However, CTCs being extremely rare in blood makes them difficult to reach. In this paper, we introduced different surface modification techniques for the enrichment and detection of MCF-7 in microfluidic biosensor applications using gold surface and EpCAM antibody. Mainly, two different mechanisms were employed to immobilize the antibodies; covalent b...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 25 January 2020Source: The Journal of Supercritical FluidsAuthor(s): P. Casademont, J. Sánchez-Oneto, A.P.J. Scandelai, L. Cardozo-Filho, J.R. PortelaAbstractThe Supercritical Water Gasification (SCWG) of black liquor (BL) to obtain hydrogen and dispose of organic waste simultaneously has been studied in a continuous reactor employing short residence times. The experiments were conducted at 600–700 °C, with times between 24.5–29.1 s, at 23 MPa and feedstock was diluted to different concentration levels (0.81–2.43 wt.%). Furthermore,...
Source: The Journal of Supercritical Fluids - Category: Chemistry Source Type: research
Publication date: Available online 25 January 2020Source: Journal of Solid State ChemistryAuthor(s): Meera Keskar, S.K. Sali, Geeta P. Shelke, Muhammed Shafeeq, S. KannanAbstractSynthesis, X-ray, chemical analysis and thermal properties of Nd doped (U, Th)O2 mixed oxides of the formula [(U0.3Th0.7)1-yNdy]O2+x; (Where y = 0–0.4) are reported in this work. The Nd doped mixed (U, Th)O2 oxides were synthesized using gel combustion method followed by heating the precursors at 1673 K in reduced atmosphere. Powder X-ray Diffraction (XRD) patterns of the mixed oxides showed retention of a single FCC phase up to 40 mo...
Source: Journal of Solid State Chemistry - Category: Chemistry Source Type: research
Publication date: 25 March 2020Source: Journal of Industrial and Engineering Chemistry, Volume 83Author(s): Xuan Thang Cao, Maheshkumar Prakash Patil, Quoc Thang Phan, Cuong M.Q. Le, Byung-Hyun Ahn, Gun-Do Kim, Kwon Taek LimAbstractThis paper reports a green and direct functionalization of poly(ethylene glycol)-graft-[furfuryl-graft-(poly(styrene-alt-maleic anhydride))] (PEG-PSMF) on the surface of single walled carbon nanotubes (SWCNTs) in aqueous media through Diels-Alder (DA) click reaction. Firstly, novel PEG grafted, furfuryl functionalized copolymers were prepared by RAFT polymerization followed by ring opening react...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Publication date: 25 March 2020Source: Journal of Industrial and Engineering Chemistry, Volume 83Author(s): Pooria Rahmani, Akbar Shojaei, Nahid Pirhady TavandashtiAbstractIn the present study, thermally oxidized nanodiamond (OND) was first modified non-covalently with dodecylamine (DDA) as corrosion inhibitor. In this respect, reactive primary amine of DDA molecule with high isoelectric point (IEP) could interact easily with negative charge carboxylic acid groups of OND. Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) proved that OND nanoparticle was successfully functionalized by DDA u...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
In this study, CaCu3Ti4O12 (CCTO) modified polyethersulfone (PES) HF membranes were prepared via dry-wet phase inversion by adding different concentration of CCTO particles (0–4 wt.%) in the dope solution. The synthesized PES/CCTO composites were characterized by viscosity measurement, scanning electron microscope, X-ray diffraction, contact angle, pore size, and pore size distribution. The flux and the photocatalytic activity of CCTO entrapped PES membranes were subsequently evaluated by crossflow ultrafiltration and the photodegradation of Rhodamine B (RhB) under UV irradiation, respectively. The pure water ...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Publication date: 25 March 2020Source: Journal of Industrial and Engineering Chemistry, Volume 83Author(s): Liangbo Zhang, Siyuan ShenAbstractIn this work, a composite material of mesoporous carbon loaded nano zero valent iron (nZVI/MC) was prepared and used as an activator of persulfate (PS) to degrade sulfamethazine (SMZ). Scanning electron microscopy (SEM) images showed nano zero valent iron (nZVI) was dispersed on the surface or in the mesopores of mesoporous carbon (MC) without aggregation. nZVI/MC has less surface area (175.63 m2 g−1) than MC (240.83 m2 g−1). The adsorption efficiency ...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
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