Lipocalin 24p3 Induction in Colitis Adversely Affects Inflammation and Contributes to Mortality

This study was carried out in accordance with the recommendations of the Case Western Reserve University IACUC committee. The protocol was approved by the Case Western Reserve University IACUC committee. Author Contributions LRD and DW helped design research studies, analyze data and write the manuscript. ZL, RL, and ND conducted experiments, acquired and analyzed data, and assisted with manuscript preparation. LDM conducted experiments and analyzed data. FC assisted with research design. Funding This work was supported by the NIH P30CA043703, K1CA113838, and R01DK081395. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments This work is supported by K1CA113838 and R01DK081395 (LRD) and Case Western Reserve University startup funds (LRD and DW). LRD is also a recipient of career developmental awards from March of Dimes and American Society of Hematology. References 1. Brestoff JR, Artis D. Commensal bacteria at the interface of host metabolism and the immune system. Nat Immunol. (2013) 14:676–84. doi: 10.1038/ni.2640 PubMed Abstract | CrossRef Full Text | Google Scholar 2. Chu H, Mazmanian SK. Innate immune recognition of the microbiota promotes host-microbial symbiosis. Nat Immunol. (2013) 14:668–75. doi: 10.1038/ni.2635 PubMed Abstract | CrossRef Full Text | Google Scholar 3. ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

This study aimed to assess the relative safety and short-term efficacy of drug-eluting bead transarterial chemoembolization (DEB-TACE) and conventional transarterial chemoembolization (c-TACE) for treating peculiar anatomical sites of gastric cancer liver metastasis. MATERIAL AND METHODS Of the 68 patients with gastric cancer liver metastases confirmed by imaging and pathology, 35 were treated with DEB-TACE and 33 with c-TACE. The DEB-TACE group comprised 26 males and 9 females aged 28-75 years (56.8±6.3), and the c-TACE group included 19 males and 14 females aged 33-77 (60.2±9.4) years. Liver functions of th...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS The network pharmacology analysis reveals the molecular biological mechanism of Artemisia annua anti-NSCLC via multiple active components, multi-channels, and multi-targets. This suggests that Artemisia annua might be developed as a promising anti-NSCLC drug. PMID: 32474568 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Soft Matter, 2020, Accepted Manuscript DOI: 10.1039/D0SM00929F, PaperOlena V. Goncharuk, Yurii M. Samchenko, Liudmyla O. Kernosenko , Olena I. Korotych, Tetiana P. Poltoratska, Natalia O. Pasmurtseva, Olena Oranska, Dariusz Sternik, Igor Mamyshev Recently, considering the potential applications of hydrogel nanocomposites in biomedical engineering, there has been a growing interest in the synthesis of hydrogels with improved mechanical properties. Among magnetic materials, iron... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - Category: Chemistry Authors: Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ01814G, PaperGurpreet Kaur, Monika Chaudhary, Kailash C Jena, Narinder Singh Abstract Environmental contamination due to increase in drug level is touching its alarming stage. There is an array of drugs such as antibiotics, antidepressants, analgesics, cancer chemotherapy drugs etc which... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Analyst, 2020, Advance Article DOI: 10.1039/D0AN00627K, PaperJun Liu, Cheng Cao We propose a novel GSH-generating prodrug to be used with a sulfonamide-induced “integrative” platform for selective cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Dr Fauci says he hasn ’t spoken to Trump in two weeks; New Zealand to consider easing restrictions earlier than planned; Mexico deaths pass 10,000. Follow the latest updatesSingapore reopens schoolsUK: Critics round on No 10 over ‘ridiculous’ rules for 14-day quarantineAustralia coronavirus updates – liveCoronavirus latest: at a glanceSee all our coronavirus coverage6.46amBSTTheAssociated Pressis carrying a report that says Chinese officials sat on releasing the genetic map, or genome, of the coronavirus for over a week after multiple government labs had fully decoded it, not sharing details key to ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Infectious diseases Science Microbiology Medical research UK news US news Australia news Source Type: news
Publication date: Available online 31 May 2020Source: Journal of Hazardous MaterialsAuthor(s): Nicolás Arancibia-Miranda, Karen Manquián-Cerda, Carmen Pizarro, Tamara Maldonado, Jonathan Suazo-Hernández, Mauricio Escudey, Nanthi Bolan, Binoy Sarkar
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
BACKGROUND: The United States (US) and Canada are in the midst of an opioid overdose epidemic. Many people who use illicit drugs (PWUD) do not call an emergency number 911 at the scene of an overdose due to fear of arrest. In the US and Canada, when an ind...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
(Medical College of Georgia at Augusta University) It's called icing sugar spleen, when the usually purplish organ looks like it has been dipped in unhealthy white icing, and the surface is bumpy and thick.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Hi everyone! I’m looking for advice on which schools to apply to in this cycle. I qualify as Disadvantaged on AMCAS and have FAP so I am able to apply to 20 schools. I’ve left off the Philly schools for personal reasons but am open to any other suggestions for my school list. cGPA: 3.7, sGPA: 3.6 For additional context, I had a really rough first 3 semesters of undergrad which included loss of income for my family, a parent’s cancer diagnosis, and 2 hospitalizations for... WAMC/School List: 3.7 cGPA/3.6 sGPA/515 MCAT
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: What Are My Chances? WAMC Medical Source Type: forums
More News: Academia | Allergy & Immunology | Anesthesia | Anesthesiology | Bladder Cancer | Bleeding | Canada Health | Cancer | Cancer & Oncology | Carcinoma | Chemistry | Colon Cancer | Colonoscopy | Colorectal Cancer | Databases & Libraries | Diets | Endocrinology | Endoscopy | Epithelial Cancer | Estradiol | Fatty Liver Disease (FLD) | Funding | Gastroenteritis | Gastroenterology | Gastroschisis Repair | Genetics | Georgia Health | Hematology | Hepatocellular Carcinoma | Hormones | Hospitals | Inflammatory Bowel Disease | Iron | Italy Health | Laboratory Medicine | Liver | Liver Cancer | Lower Endoscopy | Medical Ethics | Men | Nutrition | Oral Cancer | Pathology | Physiology | Pneumonia | Reproduction Medicine | Respiratory Medicine | Skin | Sodium | Statistics | Stem Cell Therapy | Stem Cells | Students | Study | Toxicology | Ulcerative Colitis | Universities & Medical Training | Urinary Tract Infections | Urology & Nephrology | USA Health | Weight Loss | Women