Lactobacillus helveticus SBT2171 Induces A20 Expression via Toll-Like Receptor 2 Signaling and Inhibits the Lipopolysaccharide-Induced Activation of Nuclear Factor-kappa B and Mitogen-Activated Protein Kinases in Peritoneal Macrophages

This study was carried out in accordance with the recommendations of the guidelines of the Bioscience Committee of Hokkaido University (Sapporo, Hokkaido, Japan). The protocol was approved by the Animal Care and Use Committee of Hokkaido University. Author Contributions MK carried out experimental work. MK analyzed data and wrote the manuscript. MM and TM supervised the study and reviewed the manuscript. All authors designed the study. All authors read and approved the final manuscript. Funding This study was funded by Megmilk Snow Brand Co., Ltd. The funder provided support in the form of salaries for MK and MM. Conflict of Interest Statement MK and MM are employed by Megmilk Snow Brand Co., Ltd. The content of this paper was neither influenced nor constrained by the fact. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments The authors are grateful to Dr. Naoki Fujitani (Sapporo Medical University, Sapporo, Hokkaido, Japan), Dr. Kazunobu Baba (Hokkaido University), Dr. Hisako Nakagawa, Dr. Ken Ukibe, Mr. Kei Eguchi, Mr. Takahiro Seki, and Dr. Toshihide Kabuki (Megmilk Snow Brand Co. Ltd) for their skillful collaboration and useful suggestions. The authors also appreciate the work of Ms. Yumi Matsubara (Hokkaido University) for her technical assistance. Supplementary Material The Supplementary Material for this article c...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research