Lactobacillus helveticus SBT2171 Induces A20 Expression via Toll-Like Receptor 2 Signaling and Inhibits the Lipopolysaccharide-Induced Activation of Nuclear Factor-kappa B and Mitogen-Activated Protein Kinases in Peritoneal Macrophages
Lactobacillus helveticus SBT2171 Induces A20 Expression via Toll-Like Receptor 2 Signaling and Inhibits the Lipopolysaccharide-Induced Activation of Nuclear Factor-kappa B and Mitogen-Activated Protein Kinases in Peritoneal Macrophages Michio Kawano1, Masaya Miyoshi1 and Tadaaki Miyazaki2* 1Milk Science Research Institute, Megmilk Snow Brand Co. Ltd., Saitama, Japan 2Department of Probiotics Immunology, Institute for Genetic Medicine, Hokkaido University, Hokkaido, Japan Lactobacillus helveticus SBT2171 (LH2171) has been reported to ameliorate the development of autoimmune diseases, such as collagen-induced arthritis and experimental autoimmune encephalitis in mice and inhibit interleukin (IL)-6 production in antigen-presenting cells in vitro. Regulation of cytokine production by antigen-presenting cells might be critical for the anti-inflammatory function of LH2171 in autoimmune diseases. However, the mechanism and contributing components of LH2171-mediated inhibition of IL-6 production are unclear. Here, we examined the anti-inflammatory effects of LH2171 in lipopolysaccharide (LPS)-stimulated peritoneal macrophages, as a model of antigen-presenting cells, necessary for the pathogenesis of autoimmune diseases. LH2171 significantly reduced LPS-induced expression and secretion of IL-6 and IL-1β cytokines. It also inhibited activation of nuclear factor-kappa B and mitogen-activated protein kinases (NF-κB/MAPKs). Moreover, LH2171 induced gene expression of ...
CONCLUSIONS: The development of a full triad and additional symptomatology suggests a late recognition of signs and symptoms of WE in schizophrenia. Prophylactic thiamine checks and treatment in patients with schizophrenia are relevant, and if WE is suspected adequate parenteral thiamine supplementation is necessary. Key points Only few cases of schizophrenia-related WE have been published in the literature, though challenges in diagnosing and recognising WE suggest that the vast majority of cases go undetected. Acute thiamine deficiency leads to Wernicke's Encephalopathy. Patients diagnosed with schizophrenia are at risk ...
Publication date: Available online 21 September 2020Source: The Lancet Diabetes &EndocrinologyAuthor(s): Srikanth Bellary, Abd A Tahrani, Anthony H Barnett
Publication date: Available online 21 September 2020Source: The Lancet Diabetes &EndocrinologyAuthor(s): Johannes F E Mann, Thomas Hansen, Thomas Idorn, Lawrence A Leiter, Steven P Marso, Peter Rossing, Jochen Seufert, Sayeh Tadayon, Tina Vilsbøll
Publication date: Available online 21 September 2020Source: PhytomedicineAuthor(s): Jung-Eun Lee, So Min Lee, Jeeyoun Jung
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