MicroRNA-25 upregulation protects spinal cords, yet is bad for the heart: The dark side of noncoding RNAS

We read with great interest the article published by Zhao and colleagues,1 which reported that neuroprotection of ischemic spinal cords can be enhanced by exosomes overexpressing microRNA (miRNA) 25 (miR-25). Although a growing number of novel therapies have been developed for the spinal cord damage, a trend toward the discovery of noncoding components of the genome including miRNA can significantly contribute to the clinical medicine and this study served as a prime example. Despite their promise however, the fact remains that miRNA-based therapeutics have yet to enter the clinic.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Letter to the Editor Source Type: research