Selection of New Probiotics for Endometrial Health

In this study, vaginal microbiome was divided in five biotypes, being four of them dominated by lactobacilli and considered as healthy (pH 5.0) and higher diversity. In a healthy status, microbiota is balanced and forms a stable ecological unit dominated by Lactobacillus species, which fixes pH below 5.0 and controls non-desirable groups. In a pathogenic process, the microbiome shifts to a dysbiotic state, in which lactobacilli drop, pH is increased to values above 4.5 and other groups such as Gardnerella, Atopobium, Prevotella, and Streptococcus, among others, can overgrow (Srinivasan et al., 2012). Short chain fatty acids (SCFAs) are a product of anaerobe growth, which include acetate and propionate, together with a depletion of lactic acid due to lower lactobacilli cell counts (Yeoman et al., 2013). Along with their ability to lower the pH, Lactobacillus strains have other potential characteristics that can exert control over unbalanced microorganisms such as the production of hydrogen peroxide (Sgibnev and Kremleva, 2015), bacteriocins (Ocaña et al., 1999b; Aroutcheva et al., 2001), and their capacity of adhesion (Coudeyras et al., 2008). Several studies have demonstrated there is bacterial colonization beyond the vagina, showing that the upper reproductive tract is not sterile (Baker et al., 2018). Recently, a study surveying the female reproductive tract confirmed the existence of a microbiota continuum starting in the vagina and progressing to the deepest organ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research

Related Links:

Publication date: Available online 30 May 2020Source: Life SciencesAuthor(s): Qi Fu, Zhenhai Yu
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 29 May 2020Source: Life SciencesAuthor(s): Nagesh Kishan Panchal, E.P. Sabina
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 29 May 2020Source: Carbohydrate PolymersAuthor(s): Juntao Tang, Yang Li, Yang Song, Xinyun Wu, Guipeng Yu, Kam Chiu Tam
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
In conclusion, GO decreases ligand-stimulated activities of AhR and PXR in human cells. PMID: 32464781 [PubMed - in process]
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Abstract Perfluoroalkyl substances (PFASs) are a group of man-made organic substances. Some of PFASs have been classified as persistent organic pollutants and endocrine disruptors. They might interfere with the male sex endocrine system, causing the abnormal development of the male reproductive tract and failure of pubertal onset and infertility. The present review discusses the development and function of two generations of Leydig cells in rodents and the effects of PFASs on Leydig cell development after their exposure in gestational and postnatal periods. We also discuss human epidemiological data for the effect...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
In this study, the S-PACs and their parent PACs were tested for the adsorption of three aromatic compounds-2-phenylphenol, biphenyl, and phenanthrene-with and without the presence of natural organic matter (NOM). Adsorption rates were increased for adsorption onto S-PAC as compared to PAC in all trials without NOM and in most trials with NOM. Faster adsorption onto S-PAC was found to be a result of a smaller particle size, lower surface oxygen content, larger pore diameters, and neutral pHPZC. Adsorption of a planar compound, phenanthrene, increased the most between PAC and S-PAC, while adsorption of 2-phenylphenol, a nonp...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Abstract Nitrate pollution presents a serious threat to the environment and public health. As an excellent heterotrophic denitrification carbon source, banana peel (a kind of agricultural waste) provides a feasible alternative to deal with the persistent high concentrations of nitrate pollution. Although the feasibility and economy of banana peel for denitrification have already been reported, the long-term stability and mechanism were still unclear. The coupling mechanism of organic matters and microorganism in the denitrification process was systematically investigated through a 17-cycle experiment. The results ...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
In this study, five machine learning algorithms and twelve types of molecular fingerprints were employed to generate QSAR discriminant models for mitochondrial toxicity. A threshold moving method was adopted to resolve the imbalance issue in the training data. Consensus of the models by an averaging probability strategy improved prediction performance. The best model has correct classification rates of 81.8% and 88.3% in ten-fold cross validation and external validation, respectively. Substructures such as phenol, carboxylic acid, nitro and arylchloride were found informative through analysis of information gain and freque...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Abstract Herein, the potential of bimetallic MOFs in catalytic ozonation was investigated for the first time. Three novel ozonation catalysts, i.e. cobalt-based, nickel-based and cobalt/nickel-based metal-organic frameworks (Co-MOF, Ni-MOF and Co/Ni-MOF), were synthesized, characterized by XRD, SEM, N2 sorption-desorption isotherms, FTIR and XPS, and applied in catalytic ozonation for atrazine removal. It was found that the catalysts showed outstanding performance in the catalytic ozonation, especially Co/Ni-MOF which was attributed to multiple metal sites, higher coordination unsaturation, metal centers with larg...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Abstract Heme oxygenase-1(HO-1) is a stress-inducible enzyme that mediates antioxidative and cytoprotective effects to maintain cellular redox homeostasis. In the present study, the full sequence of HO-1 was cloned from golden pompano(Trachinotus ovatus) by RT-PCR and RACE-PCR. The full cDNA sequence of HO-1 was 1349 bp in length which comprised of a 726 bp open reading frame (ORF) preceded by 262 bp 5'-untranslated region (UTR), and followed by a 360 bp 3'UTR, encoding 241 amino acid residues. Phylogenetic analysis revealed that HO-1 showed highest similarity to that of Takifugu rubripes. Tissue distribution...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
More News: Acetic Acid | Acidophilus | Acne | Allergy & Immunology | Antibiotic Therapy | Cancer | Cancer & Oncology | Cancer of the Uterus | Cervical Cancer | Chemistry | Chloride | Copper | Dermatitis | Dermatology | Education | Endometrial Biopsy | Endometrial Cancer | Endometriosis | Environmental Health | Epithelial Cancer | Finland Health | Funding | Genetics | Germany Health | Grants | Hospitals | Infertility | Insulin | Italy Health | Laboratory Medicine | Lactobacillus Acidophilus | Medical Devices | Medical Ethics | Men | Microbiology | Miscarriage | Molecular Biology | Nutrition | OBGYN | Olive Oil | Oral Cancer | Organic | Ovarian Cancer | Ovaries | Perinatology & Neonatology | Pregnancy | Probiotics | Reproduction Medicine | Skin | Skin Biopsy | Sodium | Sodium Chloride | Spain Health | Sports Medicine | Statistics | Study | Toxicology | Universities & Medical Training | USA Health | Veterinary Research | Weight Loss | Women