Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats.

Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats. Neural Plast. 2019;2019:2098083 Authors: Lv PR, Su YS, He W, Wang XY, Shi H, Zhang XN, Zhu B, Kan Y, Chen LZ, Wu QF, Yu SG, Jing XH Abstract Although referred pain or hypersensitivity has been repeatedly reported in irritable bowel syndrome (IBS) patients and experimental colitis rodents, little is known about the neural mechanisms. Spinal long-term potentiation (LTP) of nociceptive synaptic transmission plays a critical role in the development of somatic hyperalgesia in chronic pain conditions. Herein, we sought to determine whether spinal LTP contributes to the referral hyperalgesia in colitis rats and particularly whether electroacupuncture (EA) is effective to alleviate somatic hyperalgesia via suppressing spinal LTP. Rats in the colitis group (induced by colonic infusion of 2,4,6-trinitrobenzenesulfonic acid, TNBS), instead of the control and vehicle groups, displayed evident focal inflammatory destruction of the distal colon accompanied not only with the sensitized visceromotor response (VMR) to noxious colorectal distension (CRD) but also with referral hindpaw hyperalgesia indicated by reduced mechanical and thermal withdrawal latencies. EA at Zusanli (ST36) and Shangjuxu (ST37) attenuated the severity of colonic inflammation, as well as the visceral hypersensitivity and referral hindpaw hyperalgesia in coli...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research

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The objective of this presentation is to explore historical, scientific, interventional, and other differences between the two paradigms, so that innovators, researchers, practitioners, policy-makers, patients, end-users, and others can gain clarity with respect to both the explicit and implicit assumptions associated with brain advancement agendas of any kind. Over the course of three decades, a series of brain-centric, evolution-inspired insights have been articulated with increasing refinement, as principles of allostasis (Sterling and Eyer, 1988; Sterling, 2004, 2012, 2014). Allostasis recognizes that the role of the ...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Conclusion: Characteristics and nonverbal behaviors of experimenters/clinicians contribute to the elicitation and modulation of pain, placebo, and nocebo effects.IntroductionThe present qualitative review investigated whether the characteristics or nonverbal behavior (NB) of the person administrating painful stimulation affected pain or placebo/nocebo effects in the research participant. The placebo effect is a psychobiological response that may occur following the application of active and inactive interventions (1). Applying an inactive medication paired with positive information about its analgesic effects can reduce pa...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
When you hear the word meditation, you may think of sitting cross-legged with your eyes closed—breathing deeply and trying to clear your mind. While it’s true that meditation often involves quiet and focused contemplation, the whole “empty your mind” thing is a misconception, says Dr. Judson Brewer, director of research and innovation at Brown University’s Mindfulness Center. “Meditation is not about emptying our minds or stopping our thoughts, which is impossible,” Brewer says. “It’s about changing our relationships to our thoughts.” Doing so may help some stress...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Mental Health/Psychology Source Type: news
It’s hardly news that the gastrointestinal tract is important to human health: It transports food from the mouth to the stomach, converts it into absorbable nutrients and stored energy, and shuttles waste back out of the body. If you don’t properly nourish yourself, you don’t live. It’s that simple. But in recent years, scientists have discovered that the GI system has an even bigger, more complex job than previously appreciated. It’s been linked to numerous aspects of health that have seemingly nothing to do with digestion, from immunity to emotional stress to chronic illnesses, including can...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Research Source Type: news
In conclusion, the studies presented in the current review demonstrate that CBD has the potential to limit delta-9-THC-induced cognitive impairment and improve cognitive function in various pathological conditions. Human studies suggest that CBD may have a protective role in delta-9-THC-induced cognitive impairments; however, there is limited human evidence for CBD treatment effects in pathological states (e.g. schizophrenia). In short, they found that CBD may help alleviate the negative impact of a person with schizophrenia from taking cannabis, both in the psychotic and cognitive symptoms associated with schizophrenia. T...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Alternative and Nutritional Supplements Disorders General Research Treatment cannabidiol Cannabis cbd cbd oil Marijuana THC Source Type: blogs
  I previously shared Tammy’s Wheat Belly success story that illustrates just how far you can take back health and reverse numerous chronic health conditions. Besides losing over 70 pounds in weight, she also: Reversed type 2 diabetes, reducing HbA1c from the diabetic range of 8.4% to 4.9%—an ideal level. Reversed hypertension Reversed gastroesophageal reflux Reversed irritable bowel syndrome Reversed rheumatoid arthritis She has also been able to discontinue a list of toxic medications, including metformin, Prilosec, and Remicade. And, as you can readily see, turned the clock back 20 years in appearance...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates autoimmune blood sugar diabetes gastroesphageal gerd Gliadin gluten gluten-free grain-free grains high blood pressure hypertension Inflammation irritable bowel its Weight Loss wheat belly Source Type: blogs
In the seven years since the original Wheat Belly book hit bookstores and turned the nutritional world topsy-turvy and millions of people have engaged in a grain-free lifestyle, many unique lessons have been learned. Even though I had engaged the practices of this lifestyle for a number of years and in thousands of people before I broadcast these ideas through books, expanding the audience to many more people yielded feedback on an enormous scale, new lessons that even surprised me. Among the new lessons learned along the way: Plantar fasciitis—I did not expect to have so many people report that this painful conditi...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates bowel flora gluten gluten-free grain-free grains Inflammation Weight Loss Source Type: blogs
Abstract Opioids have been used for centuries, mostly as a sedative and to treat pain. Currently, they are used on a global scale for the treatment of acute and chronic pain in diseases as osteoarthritis, fibromyalgia, and low back pain. Binding of opioids on opioid receptors can cause a range of different effects such as changes in stress response, analgesia, motor activity and autonomic functions. This review provide a synthetic summary of the most recent literature on the use of drugs acting on mu-receptors to treat two prevalent functional bowel disorders, presenting with opposite bowel habit. Eluxadoline and ...
Source: Current Opinion in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Opin Pharmacol Source Type: research
For over 20 years, Linda Buonanno lived in fear that her irritable bowel syndrome (IBS) would suddenly interrupt her daily routine with frequent trips to the bathroom and unbearable cramping. Buonanno, now a 71-year-old medical assistant and hairdresser from Methuen, Mass., tried everything from drugs to dairy-free diets. Nothing worked. She remembers a particularly tough period over 10 years ago, when she was working on the factory floor of a medical-device company for up to 10 hours a day, six days a week. When an IBS episode would strike, her co-workers would cover for her as she huddled in a corner, keeled over in pain...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized medicine Research Source Type: news
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