Scientists Plan To Start Human Trials Testing CRISPR Soon

The powerful gene-editing technique is moving out of the lab and into the clinic. Trials will use CRISPR to try to treat a variety of diseases, ranging from cancer and blindness to blood disorders.
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news

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Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Researchers used an experimental gene therapy to develop a possible treatment for a rare and deadly immune disorder known as “bubble boy” disease, the National Institutes of Health (NIH) announced Wednesday. Because of a gene mutation, babies who are born with X-linked severe combined immunodeficiency (X-SCID) do not develop immune cells properly, leaving them highly susceptible to infections. The condition, which strikes up to one in 50,000 newborns, primarily affects boys and requires extreme measures to prevent infection. In one famous case, a boy with SCID, David Vetter, lived in a sterile plastic “bu...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Research Source Type: news
This could be a crucial year for the powerful gene-editing technique CRISPR as researchers start testing it in patients to treat diseases such as cancer, blindness and sickle cell disease.(Image credit: Molekuul/Getty Images/Science Photo Library)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
Christine I. Alston1,2 and Richard D. Dix1,2* 1Department of Biology, Viral Immunology Center, Georgia State University, Atlanta, GA, United States 2Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, United States Suppressor of cytokine signaling (SOCS) proteins provide selective negative feedback to prevent pathogeneses caused by overstimulation of the immune system. Of the eight known SOCS proteins, SOCS1 and SOCS3 are the best studied, and systemic deletion of either gene causes early lethality in mice. Many viruses, including herpesviruses such as herpes simplex virus and cytomega...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In conclusion, the reduction in the analgesic action of opioids in DNP might be a consequence of MOR reduction, particularly in the spinal cord. Therefore, developing opioids of high efficacy might provide analgesia exceeding that of currently available opioids. Introduction Neuropathic pain (NP) is a chronic pain condition that limits patients to fully achieve their daily tasks. Consequently, NP has significant impact on the economic welfare of the society (Bouhassira et al., 2008; Gaskin and Richard, 2012). Therefore, to find drugs satisfactorily treating NP is a major clinical goal. The management of severe acut...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
WIRED Health, now in its sixth year, returned to London’s Francis Crick Institute. The event was opened by Crick Institute director Paul Nurse who introduced the institute and its mission to understand the fundamental biology of human heal...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Medicine Public Health Society Source Type: blogs
This study defines a new clinically relevant concept of T-cell senescence-mediated inflammatory responses in the pathophysiology of abnormal glucose homeostasis. We also found that T-cell senescence is associated with systemic inflammation and alters hepatic glucose homeostasis. The rational modulation of T-cell senescence would be a promising avenue for the treatment or prevention of diabetes. Intron Retention via Alternative Splicing as a Signature of Aging https://www.fightaging.org/archives/2019/03/intron-retention-via-alternative-splicing-as-a-signature-of-aging/ In recent years researchers have inv...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In his new book, Deep Medicine, the cardiologist argues that artificial intelligence can bring humanity back to medicine. You tweet several times a day about the latest medical studies. Do you really read all of those articles? Every one of the 18,000 tweets come from me. People think I have an army of people to help me–no. I’m an information junkie. Ever since I was a kid I’ve been an incessant reader. I apportion time every day–a couple of hours in the morning and the evening. What is the biggest problem you see in medicine today? What’s happened is an erosion of the relationship, due to the...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Artificial Intelligence Life Reinvented medicine Source Type: news
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Follow the simple Wheat Belly No Change Rule for fingerstick blood sugars and you maximize your chances of getting rid of type 2 diabetes and accelerating weight loss. By becoming non-diabetic or at least minimizing it, you are freed from the awful health consequences of this disease, as well as extending life considerably. The No Change Rule also helps reverse insulin resistance that blocks weight loss. Transcript: Hi everybody. Doctor William Davis here. I want to talk about something I call the Wheat Belly “No Change Rule” — that is, no change in blood sugar — comparing a pre-meal to ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates diabetes no change rule undoctored Weight Loss wheat belly Source Type: blogs
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