Race and PSA Impact Mortality in Low-Risk Prostate Cancer Race and PSA Impact Mortality in Low-Risk Prostate Cancer

Dr Gerald Chodak discusses recent findings suggesting that race does not affect mortality risk when PSA levels are below 4 ng/mL.Medscape Urology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Urology Commentary Source Type: news

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Source: Dermatology - Category: Dermatology Source Type: research
Conclusion: The link of obesity and cancer is analyzed under the aspect of adipokine-regulated miRs. At the same time the impact of miR abundance is considered as a regulatory variable. This context offers new strategies for tumor therapy and diagnostics.Obes Facts 2019;12:211 –225
Source: Obesity Facts - Category: Eating Disorders & Weight Management Source Type: research
Authors: Liu B, Xu M, Guo Z, Liu J, Chu X, Jiang H Abstract The aim of the present study was to investigate whether interleukin-8 (IL-8) enhances the ability of prostate cancer bone metastasis by influencing the coding level of bone sialoprotein (BSP). Cultured prostate cancer cell lines LNCaP (androgen dependent) and DU145 (androgen independent) were divided into three groups: IL-8 treatment group; IL-8 receptor inhibitor (SB225002) treatment group; and control group. Western blotting and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) were used to detect BSP protein and mRNA expression leve...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, the present study may lead to further investigation of the function role of exosomal miR-375 in the activation and differentiation of osteoblasts in PCa. PMID: 30988815 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
An artificial intelligence (AI) algorithm called FocalNet was able to identify...Read more on AuntMinnie.comRelated Reading: Ga-68 PSMA-PET/CT for prostate wins Australian favor AIUM: TRUS or MRI for prostate diagnosis? MRI can be safe for patients with implanted devices Nvidia debuts AI toolkit for radiologists at GTC 2019 AI singles out high-risk prostate cancer on mpMRI
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
CONCLUSION: Adding surgery in a multimodal treatment model in high-risk prostate cancer showed significantly better survival outcome compared with the current standard of radiotherapy. Surgery in this group is, therefore, compelling and that also includes a clinical T3-stage of the disease. The study is limited by possible selection bias for the two treatment models. PMID: 30990112 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
Conclusion In this article, we proposed a novel method LPI-IBNRA for predicting lncRNA-protein interactions, based on the known lncRNA-protein interactions, lncRNA expression similarity and protein-protein interactions. We integrated the known interactions and similarity as the initial resource scores for a two-round resource allocation of a bipartite network recommendation. Furthermore, we optimized the weight matrix by eliminating second-order correlations appropriately, to obtain the final result of lncRNA-protein interaction prediction. We finally acquired gratifying and reliable prediction performance in LOOCV, 10-fo...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
In this study we adopted an all-in-one method. Primers designed according to the two gRNA sequences and the tracRNA-U6 vector sequences were used to produce a gRNA1-tracRNA-U6-gRNA2 fragment. Then the proper fragment was ligated into the lentiCRISPRv2 vector and verified by sequencing. Lentiviral Packaging and Stable Cell Line Screening The constructed eukaryotic expression vector and gene knockdown vector were transfected into the 293T cells with the packaging plasmids psPAX2 and pMD2.G using Lipofectamine 2000 (Thermo Fisher, Massachusetts, USA). The lentivirus was harvested 48 h after transfection, and the lentivirus ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: Our data suggests that the precancerous unstable CNVs with potentially predisposing genetic backgrounds may foster the onset of driver mutations and the development of independent SM-GGNs during the local stimulation of mutagens. Introduction The widespread use of advanced chest computed tomography (CT) for lung cancer screening has facilitated the detection of ground-glass nodules (GGNs) (1–3). Recent data indicates that up to 20% of GGN patients (3% of the screening population) are diagnosed with synchronous multiple ground-glass nodules (SM-GGNs) (4). GGNs are like atypical adenomatous hyperplasi...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions In this review, we analyzed mechanisms through which mitobolites, a distinct set of mitochondria-generated metabolites, can be released from mitochondria and then act as second messengers that contribute to cellular and organismal aging by regulating longevity-defining processes outside of mitochondria. Our analysis indicates that in eukaryotes across phyla, these second messengers of cellular aging exhibit the following common features: (1) they are produced in mitochondria in response to certain changes in the nutrient, stress, proliferation or age status of the cell; it remains unknown, however, what kind o...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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