Gilead teams up with insitro for experimental NASH treatments

Gilead Sciences Inc said on Tuesday it will partner with privately held insitro to develop therapies for a fatty liver disease called non-alcoholic steatohepatitis (NASH), as the drugmaker tries to overcome its recent setback in developing NASH treatments.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Contributors : Oliver Krenkel ; Jana Hundertmark ; Ali T Abdallah ; Marlene Kohlhepp ; Tobias Puengel ; Tilman Roth ; Diogo P Branco ; Jana C Mossanen ; Tom Luedde ; Christian Trautwein ; Ivan G Costa ; Frank TackeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObjective: Bone marrow-derived myeloid cells accumulate in the liver as monocytes and macrophages during the progression of obesity-related non-alcoholic fatty liver disease (NAFLD) to steatohepatitis (NASH). Myeloid cells comprise heterogeneous subsets, and dietary overnutrition may affect macrophages in liver and bone marrow....
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Ali Mahzari1, Songpei Li1, Xiu Zhou1,2, Dongli Li2, Sherouk Fouda1, Majid Alhomrani1, Wala Alzahrani1, Stephen R. Robinson1 and Ji-Ming Ye1,2* 1Lipid Biology and Metabolic Disease Laboratory, School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia 2School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China The present study investigated the effects of matrine on non-alcoholic steatohepatitis (NASH) in mice induced by a methionine choline-deficient (MCD) diet and the mechanism involved. The study was performed in C57B/6J mice fed a MCD diet for 6 weeks to induce NAS...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
(CNN) — Whether you eat breakfast might be linked with your risk of dying early from cardiovascular disease, according to a new study. Skipping breakfast was significantly associated with an increased risk of cardiovascular-related death, especially stroke-related death, in the study published in the Journal of the American College of Cardiology on Monday. After a person’s age, sex, race, socioeconomic status, diet, lifestyle, body mass index and disease status were taken into account, the study found that those who never had breakfast had a 87% higher risk of cardiovascular mortality compared with people who h...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Heart Disease Source Type: news
ConclusionOnly a small number of ALT tests performed during MTX therapy in RA capture an elevation. A pre ‐treatment elevation of ALT was the strongest predictor for early and recurrent ALT elevations during therapy. This study supports a more individualized approach to monitoring and handling of ALT elevations during MTX therapy in RA than recommended in current guidelines.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Authors: Di Sessa A, Marzuillo P, Guarino S, Cirillo G, Miraglia Del Giudice E PMID: 31002001 [PubMed - as supplied by publisher]
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Authors: Tokodai K, Karadagi A, Kjaernet F, Romano A, Ericzon BG, Nowak G Abstract OBJECTIVES: Nonalcoholic steatohepatitis (NASH), which is a common and increasing indication for liver transplantation (LT), is known to recur after LT. Since the recurrence of NASH can lead to graft failure, the identification of predictive factors is needed and preventive strategies should be implemented. METHODS: We retrospectively examined 95 patients who had undergone LT for NASH or alcoholic liver disease (ALD) as a primary indication. We evaluated peritransplant characteristics and histological findings 1-year post LT amon...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
In this study, in seven distinct multi-generation families we found the causative gene for a rare Mendelian form of NAFLD. In a large Italian family with nine affected members with NAFLD and/or dyslipidemia, whole exome sequencing identified a heterozygous stop codon mutation in ABHD5.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research
The DIAMOND ™ model is an inbred isogenic C57BL/6J x 129S1/SvImJ mouse that develops features of the human metabolic syndrome including obesity, the spectrum of non-alcoholic fatty liver disease (NAFLD), and diabetes. Approximately 10% also develop a spontaneous dermatitis after being placed on Western Diet ( WDSW). The aim of this study was to investigate histologic features of the observed cutaneous inflammation and to screen for alterations in hepatic gene expression that may impact the skin. Lesional and adjacent normal skin were harvested from mice on WDSW and age-matched negative controls on a norm al chow/norm...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research
Rho ‐associated, coiled‐coil‐containing protein kinase 1 might have applications as a potential therapeutic target for the treatment of non‐alcoholic fatty liver disease.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Commentary Source Type: research
Source: Critical Reviews in Food Science and Nutrition - Category: Nutrition Authors: Source Type: research
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