White Matter Tract Alterations in Drug-Na ïve Parkinson's Disease Patients With Excessive Daytime Sleepiness

This study aimed to investigate white matter microstructure alterations by using connectometry in patients with PD-EDS, in comparison to PD-nEDS and healthy individuals. Materials and Methods Participants Participants involved in this research were recruited from Parkinson's Progression Markers Initiative (PPMI, http://www.ppmi-info.org/). The study was approved by the institutional review board of all participating sites in Europe, including Attikon University Hospital (Greece), Hospital Clinic de Barcelona and Hospital Universitario Donostia (Spain), Innsbruck University (Austria), Paracelsus-Elena Clinic Kassel/University of Marburg (Germany), Imperial College London (UK), Pitié-Salpêtrière Hospital (France), University of Salerno (Italy), and in the USA, including Emory University, Johns Hopkins University, University of Alabama at Birmingham, PD and Movement Disorders Center of Boca Raton, Boston University, Northwestern University, University of Cincinnati, Cleveland Clinic Foundation, Baylor College of Medicine, Institute for Neurodegenerative Disorders, Columbia University Medical Center, Beth Israel Medical Center, University of Pennsylvania, Oregon Health & Science University, University of Rochester, University of California at San Diego, University of California, San Francisco. Written informed consent was obtained from all participants before study enrolment. To be enrolled into the PPMI study, all patients were required...
Source: Frontiers in Neurology - Category: Neurology Source Type: research