Reply

We thank Ms Brown and Dr Gutierrez for their comments regarding our recent publication of the ASBMT CRS and ICANS Consensus Grading [1], and we agree that there are significant clinical differences between patients requiring a low dose versus a high dose of 1 vasopressor. This was an active area of discussion among the larger group. However, we expressly stated that the Consensus Grading is not a treatment guideline, and no inference in such regard should be made. Rather, grading of CRS is entirely dependent on the interventions the patient requires and is not a meant as a tool to suggest one intervention or another.

Source: Biology of Blood and Marrow Transplantation - March 21, 2019 Category: Hematology Authors: Daniel W. Lee, Elena Mead, Bianca D. Santomasso, Cameron J. Turtle, Stephan A. Grupp, Sattva S. Neelapu Source Type: research