Endothelial-Dependent and Independent Vascular Relaxation Effect of Tetrahydropalmatine on Rat Aorta
Endothelial-Dependent and Independent Vascular Relaxation Effect of Tetrahydropalmatine on Rat Aorta Zhong-Yan Zhou1,2†, Wai-Rong Zhao1†, Wen-Ting Shi1†, Ying Xiao1, Zi-Lin Ma1, Jin-Gui Xue3, Lun-Qing Zhang4, Qing Ye1, Xin-Lin Chen1* and Jing-Yi Tang1,5* 1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China 2State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China 3Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China 4Faculty of Health Sciences, University of Macau, Macau, China 5Cardiac Rehabilitation Center of Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China Tetrahydropalmatine (THP) is an active natural alkaloid isolated from Corydalis yanhusuo W.T. Wang which has been widely used for treating pain and cardiovascular disease in traditional Chinese medicine. Previous studies suggested THP have various pharmacological effects in neural and cardio tissue while the vascular reactivity of THP was not fully established. The present study found that THP relaxed rat aorta which contracted by phenylephrine (Phe), KCl, and U46619. The vascular relaxation effect of THP was partially attenuated by PI3K inhibitor wortmannin, Akt inhibitor IV, endothelial nitric oxide synthetase (eNOS) inhibitor L-NAME, guanylate cyclase inhibitors and the mechanical removal of endotheliu...
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