In Vitro Study of the Enzymatic and Nonenzymatic Conjugation of Treosulfan with Glutathione
ConclusionTreosulfan does not undergo either spontaneous or enzymatic conjugation with GSH at a noticeable rate. The result indicates that the clearance of treosulfan is independent of glutathioneS-transferase activity, GSH stores, and co-administration of drugs utilizing the GSH metabolic pathway.
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
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