Epistatic Interaction Between 5-HT1A and Vascular Endothelial Growth Factor Gene Polymorphisms in the Northern Chinese Han Population With Major Depressive Disorder

Conclusions: The interactions between 5-HT1A and VEGF gene polymorphisms may play a key role in the development of MDD in the Northern Chinese Han population.IntroductionMajor depressive disorder (MDD) is one of the most common complex mental disorders, with symptoms that include loss of interest, periodic depression, and thoughts of suicide. Epidemiologic studies have shown that MDD afflicted an estimated 7%–11% of the general population (1, 2); yet, the underlying mechanism of MDD remains unclear. Genetic factors are likely to play a critical role in its etiology with the total contribution of heritability estimated at approximately 40% (3). Results from family, twin, and adoption studies provided further strong evidence for a genetic component to MDD (4); however, there are studies suggesting that single genetic loci offer weak predictive power for the identification of MDD (5). A large body of evidence found that gene–gene interactions are intricately involved in the phenotypic effect of variation in complex psychiatric diseases, particularly when a specific individual genetic variant is present (6, 7). There are numerous studies that suggest that overlaps exist between biological mechanisms underlying MDD (8). Thus, identifying the genetic mechanisms of MDD susceptibility may contribute to a better understanding of the etiological features of MDD (9).Previous studies of neuroimaging and postmortem MDD patients found that the average volume of the hippocampus ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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This study constituted the second phase of a World Anti-Doping Agency (WADA) supported Social Science initiative.
Source: Performance Enhancement and Health - Category: Sports Medicine Source Type: research
Hey i wanted to know if its ok to take the requisites at a commuity college, i took bio 1 and 2 with labs and chemestry 1 and lab, so far i have 46 credits but will have 50 this summer because i am taking chem 2 with lab. planning on doing organic chemestry 1 with lab , trigonometry . for spring organic chemstry 2 with lab , calculus. Not sure if I should take physics there too.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Medical - MD Source Type: forums
Publication date: 1 October 2019Source: Personality and Individual Differences, Volume 148Author(s): Shuang Gao, Sander Thomaes, Wim Van Den Noortgate, Xiaochun Xie, Xiangkui Zhang, Suiping WangAbstractThe present study examined potential changes in narcissistic traits of Chinese youth from 2008 to 2017. A cross-temporal meta-analysis involving 29 independent samples (N = 14,795) found a downward temporal trend: Mean scores on the Narcissistic Personality Inventory and Narcissistic Personality Inventory for Chinese are significantly negatively associated with year of data collection, weighted by sample size (β =...
Source: Personality and Individual Differences - Category: Psychiatry & Psychology Source Type: research
Conclusion It is clear that clinically, there is still much to be learnt about alexithymia and its relationship with a range of related phenomena. Firstly, is alexithymia a continuous and stable trait independent of psychological or somatic symptomology that is developed during childhood? Or is it instead a reactive state induced by trauma and distress at any age, which serves to defend against intense and upsetting emotions? This impacts on treatment options. For example, should we be focussing on early childhood interventions which target the child's emotional environment and parenting to encourage emotional exp...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
This study will be conducted in the city of Porto Alegre in the state of Rio Grande do Sul in far-southern Brazil. This region has Portuguese, Italian, German, and African influence. It has a population of 1.4 million, and it is the 10th most populous city in Brazil. Its ethnic distribution is as follows: White (79.2%), Black (10.2%), and Pardo (multiracial) people (10.6%). Its religious distribution is as follows: Catholic (83%), Protestant (9%), and others and atheists (8%). Brazil is a country with a high level of religiosity, and it is common for people to associate improvements in their health as being due to their fa...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Are Suicide and Addiction Linked? When someone is suffering from an issue with addiction, there are many complications that can come along with that. These can include legal issues, family problems, declining health and even suicide. Suicide and addiction are absolutely linked. Addiction not only exponentially increases the likelihood that someone will commit suicide, but substances are often used as a means to commit suicide via overdose. According to the CDC, one in three people who die from suicide are under the influence of drugs. They are typically opiates such as oxycodone or heroin, or alcohol. When someone is suffe...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction Recovery Addiction Stories Addiction to Pharmaceuticals Addiction Treatment and Program Resources Depression Depression Treatment Mental Health anxiety Post Traumatic Stress Disorder PTSD suicide suicide and add Source Type: blogs
Gabe Howard’s biggest fear is that his bipolar disorder will get worse. “I’m more worried about the symptoms of bipolar disorder coming back than I am about anything else. Literally anything else. I’ll walk through the streets after midnight in New York City and not be a bit concerned about being attacked — but I’ll be terrified of losing everything to bipolar disorder.” Elaina J. Martin also fears getting sicker. “I worry I will get in a depression so dark I will become suicidal because it has happened before.” She, too, worries about the mania returning. &ld...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Creativity Grief and Loss Peer Support Self-Help Bipolar Disorder bipolar mania Depressive Episode Manic Episode Source Type: blogs
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research
Anxiety disorders like social anxiety disorder, obsessive compulsive disorder, agoraphobia, panic disorder and general anxiety are the most common forms of mental illness in the U.S. An estimated 18 percent of all American adults have an anxiety disorder, costing more than $42 billion a year.  America is unique in this regard, according to the largest ever global analysis. Some regions of the world, including the U.S. but also Western Europe, have higher rates of anxiety disorders in general. What's more, some groups within the U.S. have a higher risk of anxiety disorder diagnosis than others. Olivia Remes, lead autho...
Source: Science - The Huffington Post - Category: Science Source Type: news
Conclusion The SCIP is reliable and valid diagnostic interview, is compatible with experimental psychopathology and personalized psychiatry research, and is in line with the NIMH RDoC framework. The SCIP Instruction Manual is also available for download by visiting http://innovationscns.com/wp-content/uploads/SCIP_Instruction_Manual_2015.pdf. Acknowledgment Dr. Aboraya had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses. References 1.     Stone M. Healing the Mind: A History of Psychiatry from Antiquity to the Present. In: ...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools Current Issue Evaluations Psychiatry Reliability of Diagnoses Review Scales Trial Methodology descriptive psychopathology diagnostic criteria dimensional scores Psychiatric interview SCIP Standard for Clinicians Source Type: research
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