microRNA-152 inhibits cell proliferation, migration and invasion in breast cancer.

microRNA-152 inhibits cell proliferation, migration and invasion in breast cancer. Oncol Res. 2019 Apr 08;: Authors: Maimaitiming A, Wusiman A, Aimudula A, Kuerban X, Su P Abstract The aim of the present study was to investigate the roles of microRNA-152 (miR-152) in the initiation and progression of breast cancer. The expression level of miR-152 was detected in human breast cancer tissue and a panel of human breast cancer cell lines using qRT-PCR. Results found that miR-152 expression was significantly down-regulated in breast cancer tissue samples compared to adjacent noncancerous tissues as well as in breast cancer cell lines. Overexpression of miR-152 significantly suppressed breast cancer cell proliferation, migration and invasion. Luciferase reporter assay results found that ROCK1 is a direct and functional target gene of miR-152 in breast cancer. In addition, downexpression of ROCK1 could inhibit breast cancer cell proliferation, migration and invasion. These findings indicate that miR-152 inhibited breast cancer growth and metastasis through negative regulation of ROCK1 expression. This data suggests that miR-152/ROCK1 pathway may be a useful therapeutic target for breast cancer treatment. PMID: 30982494 [PubMed - as supplied by publisher]
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research