Paliperidone extended-release in the short- and long-term treatment of schizophrenia.

Paliperidone extended-release in the short- and long-term treatment of schizophrenia. Riv Psichiatr. 2019 Mar-Apr;54(2):43-58 Authors: Valsecchi P, Garozzo A, Nibbio G, Barlati S, Deste G, Turrina C, Sacchetti E, Vita A Abstract Paliperidone is a second-generation antipsychotic drug belonging to the class of benzisoxasole derivatives. Paliperidone is the major active metabolite of risperidone (9-OH-risperidone) and, as such, is comparable to the latter in terms of pharmacodynamic properties. However, due to its peculiar characteristics, paliperidone may be particularly useful in the treatment of schizophrenic patients. In this critical review of the literature the efficacy and tolerability in the short- and in the long-term have been evaluated in patients with schizophrenia. Taking into account the tolerability and efficacy data, together with the use of innovative sustained-release formulation, with a peculiar pharmacokinetic profile that allows single daily administration, paliperidone can be considered a valid option both for the short and the long-term treatment of schizophrenia. PMID: 30985829 [PubMed - in process]
Source: Rivista di Psichiatria - Category: Psychiatry Tags: Riv Psichiatr Source Type: research