Viruses, Vol. 11, Pages 350: Whole-Genome Analysis of Human Papillomavirus Type 16 Prevalent in Japanese Women with or without Cervical Lesions

Viruses, Vol. 11, Pages 350: Whole-Genome Analysis of Human Papillomavirus Type 16 Prevalent in Japanese Women with or without Cervical Lesions Viruses doi: 10.3390/v11040350 Authors: Yusuke Hirose Mamiko Onuki Yuri Tenjimbayashi Mayuko Yamaguchi-Naka Seiichiro Mori Nobutaka Tasaka Toyomi Satoh Tohru Morisada Takashi Iwata Tohru Kiyono Takashi Mimura Akihiko Sekizawa Koji Matsumoto Iwao Kukimoto Recent large-scale genomics studies of human papillomaviruses (HPVs) have shown a high level of genomic variability of HPV16, the most prevalent genotype in HPV-associated malignancies, and provided new insights into the biological and clinical relevance of its genetic variations in cervical cancer development. Here, we performed deep sequencing analyses of the viral genome to explore genetic variations of HPV16 that are prevalent in Japan. A total of 100 complete genome sequences of HPV16 were determined from cervical specimens collected from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer, or without cervical malignancies. Phylogenetic analyses revealed the variant distribution in the Japanese HPV16 isolates; overall, lineage A was the most prevalent (94.0%), in which sublineage A4 was dominant (52.0%), followed by sublineage A1 (21.0%). The relative risk of sublineage A4 for cervical cancer development was significantly higher compared to sublineages A1/A2/A3 (odds ratio = 6.72, 95% confidence interval = 1.78&...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research