Phenylketonuria Diet Promotes Shifts in Firmicutes Populations

In this study we compared the gut microbial communities of children with PKU and with mild hyperphenylalaninemia (MHP, unrestricted diet). For each group, we enrolled 21 children (4–18 years old), for a total dataset of 42 subjects. We assessed dietary intake and performed gut microbiota analysis by sequencing the V3–V4 hypervariable regions of the 16S rRNA gene. Short chain fatty acids (SCFAs) were quantified by gas chromatographic analysis. While alpha-diversity analysis showed no significant differences between PKU and MHP groups, microbial community analysis highlighted a significant separation of the gut microbiota according to both unweighted (p = 0.008) and weighted Unifrac distances (p = 0.033). Major differences were seen within the Firmicutes phylum. Indeed, PKU children were depleted in Faecalibacterium spp. and enriched in Blautia spp. and Clostridium spp (family Lachnospiraceae). We found a divergent response of members of the Firmicutes phylum with respect to daily glycemic index, higher in PKU children. Faecalibacterium prausnitzii, unclassified Ruminococcaceae and, to a lesser extent Roseburia spp. negatively correlated with glycemic index, whereas unclassified Lachnospiraceae were positively associated. Indicator species analysis suggested F. prausnitzii be related to MHP status and Ruminococcus bromii to be associated with PKU. Despite PKU children having a higher vegetable and fiber intake, resembling a vegan diet, their gut microbial profile is...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research

Related Links:

Abstract A new and facile method for selective measurement of profenofos (PFF) using a simple flow-injection system with a molecularly-imprinted-polymer-coated carbon nanotube (3D-CNTs@MIP) amperometric sensor is proposed. The 3D-CNTs@MIP was synthesized by successively coating the surface of carboxylated CNTs with SiO2 and vinyl end groups, then terminating with molecularly imprinted polymer (MIP) shells. MIP was grafted to the CNT cores using methacrylic acid (MAA) monomer, ethylene glycol dimethacrylate (EGDMA) as cross linker, and 2,2'-azobisisobutyronitrile (AIBN) as initiator. We constructed the PFF sensor b...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Publication date: Available online 18 June 2019Source: Advances in Space ResearchAuthor(s): Leonardo Marini-Pereira, Kelias de Oliveira, Lucas A. Salles, Alison de O. Moraes, Eurico R. de Paula, Marcio Tadeu de Assis Honorato Muella, Waldecir J. PerrellaAbstractThe ionosphere in low-latitude regions has intense dynamics with great variability – not only spatially but also temporally. The most critical effect found in the low-latitude region is the scintillation in phase and amplitude due to plasma bubble occurrence in the ionospheric layer. To augmentation systems like GBAS or SBAS, designed to provide Category-I (CA...
Source: Advances in Space Research - Category: Science Source Type: research
The objectives of this study were to investigate the underlying mechanism of PPARα, LXRα, ChREBP, and SREBP-1c at the level of gene and protein expression with high-energy diets in liver and skeletal muscle. MATERIALS AND METHODS: Metabolic changes with consumption of high fat (Hfat), high sucrose (Hsuc) and high fructose (Hfru) diets were assessed. Levels of mRNA and protein of PPARα, LXRα, ChREBP, and SREBP-1c were investigated. Body weight changes, histological structure of liver and plasma levels of some parameters were also examined. RESULTS: In Hfru group, body weights were higher than other groups (P
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
We examined fifteen years of cross-sectional data (2002–2016, N = 234,803) from the National Survey on Drug Use and Health. Our main outcome was youth self-reported (no/yes) past-year participation in a pregnancy or STI prevention program. Survey adjusted prevalence estimates and logistic regression analysis were used to examine trends in participation. Youth participation in pregnancy and STI prevention programming decreased significantly from a high of 15% in 2003 to a low of 7% in 2016. Representing a 53% proportional decline in youth participation, this downward trend was significant even when controlling for...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 18 June 2019Source: Preventive MedicineAuthor(s): Claudia Trudel-Fitzgerald, Peter James, Eric S. Kim, Emily S. Zevon, Francine Grodstein, Laura D. KubzanskyAbstractGreater levels of psychological well-being are associated with reduced disease and mortality risk, and lifestyle habits may be potential mechanisms underlying these relationships. Prospective studies show that positive psychological factors enhance the likelihood of adopting specific health behaviors; yet, whether they promote the adoption of multiple healthy behaviors, which can have a multiplicative effect on disease and mor...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 18 June 2019Source: Preventive MedicineAuthor(s): Benjamin D. Hallowell, Meheret Endeshaw, Matthew T. McKenna, Virginia Senkomago, Hilda Razzaghi, Mona SaraiyaAbstractFrom 1970 to 2010 the foreign-born population in the United States has rapidly increased from 9.6 to 40.0 million individuals. Historically, differences in cancer rates have been observed between US-born and foreign-born individuals. However, comprehensive and up-to-date data on US cancer rates by birth place is lacking. To compare cancer mortality rates among foreign and US-born individuals, population-based cancer mortalit...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionsFor patients with Type 2 diabetes, team-based care improves blood glucose, blood pressure, and lipid levels.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: July 2019Source: American Journal of Preventive Medicine, Volume 57, Issue 1Author(s): Community Preventive Services Task Force
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionIs convenient to consider a medication induced AP in patients without clear causative agent, such as the VA case presented. An etiological diagnosis algorithm of exclusion is proposed, for an adequate therapeutic approach in medication induced PNH. Algorithm validation is required.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 17 June 2019Source: Journal of the American College of RadiologyAuthor(s): Patricia Balthazar, Gelareh Sadigh, Danny Hughes, Andrew B. Rosenkrantz, Tarek Hanna, Richard DuszakAbstractPurposeThe aim of this study was to examine changing characteristics of utilization and potential disparities in US emergency department (ED) patients undergoing CT of the abdomen and pelvis (CTAP) for suspected urolithiasis.MethodsA retrospective study was conducted among all patients from 2006 to 2015 with a primary diagnosis of suspected urolithiasis within the Nationwide Emergency Department Sample, the l...
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
More News: Academia | African Health | Anorexia | Bacteroides Infection | Balanced Diets | Brain | Brain Cancers | Brazil Health | Canada Health | Carbohydrates | Cardiology | Chemistry | Child Development | Children | Databases & Libraries | Diabetes | Diets | Eating Disorders & Weight Management | Endocrinology | Environmental Health | Fruit | Gastroenterology | Genetics | Georgia Health | Germany Health | Grants | Heart | Insulin | Italy Health | Legislation | Liver | Liver Disease | Medical Ethics | Men | Metabolic Syndrome | Microbiology | Neurology | Neuroscience | Nutrition | Obesity | Pediatrics | Perinatology & Neonatology | Phenylketonuria | Probiotics | Psychology | Reproduction Medicine | Rural Health | Science | Statistics | Students | Study | Sugar | Toxicology | Universities & Medical Training | Urology & Nephrology | USA Health | Vegan | Vegetables | Vegetarian