Phenotypic Plasticity of Staphylococcus aureus in Liquid Medium Containing Vancomycin

In this study, the multivariate linear mixed model (LMM) was used to calculate the P-value to determine interesting SNPs at each time point using GEMMA software v0.97 (Zhou and Stephens, 2014). Growth data from both untreated and vancomycin-treated group formed the bivariate phenotype, which differs hugely from the univariate phenotype. Therefore, LMM developed for univariate phenotype cannot be applied to analyze correlated phenotype directly; methods allowing LMM algorithm specific to multivariate and correlated phenotype [multivariate LMMs (mvLMMs)] are in urgent need. GEMMA software could extend a standard LMM to mvLMMs, which simultaneously analyze correlated phenotypes but without losing mapping accuracy. Like traditional LMM model, population structure and kinship were all considered to be implemented in multivariate LMM. GEMMA fit a mvLMM in the following form: 𝐘 = ⁒ 𝐗 ⁒ B + 𝐒 ⁒ A + 𝐐𝐕 + 𝐔 + 𝐄 ; 𝐔 ∼ M ⁒ N n × 2 ⁒ ( 𝟎 , 𝐊 , V g ) , 𝐄 ∼ M ⁒ N n × 2 ⁒ ( 𝟎 , I n × n , V e ) . Consider the bivariate phenotype from twogroups, n strains in mapping population constituted an n by 2 matrix of Y. X is a matrix full of 1s and XB simply represents the fixed effects other than SNP and the population structure. A is an 2...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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CONCLUSION: Arterial hypertension and elevated diastolic blood pressure are associated with a risk for AS requiring surgery in subjects below 60 years of age. Strict blood pressure control in this group is strongly advocated to avoid other cardiovascular diseases correlated to hypertension. If hypertension and elevated diastolic blood pressure are risk factors for developing AS requiring surgery need further investigations. Notably, elevated fasting glucose levels were related to AS requiring surgery in older adults without concomitant CAD. PMID: 31109205 [PubMed - in process]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
CONCLUSIONS: Current literature show similar risks for bacterial pathogens. Studies are limited for viral and parasitic pathogens. The evaluated risk-factors for PI-IBS varied among the included studies and the existing evidence is insufficient to identify pathogen-specific risk factors. PMID: 31112663 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Publication date: Available online 21 May 2019Source: Journal of Environmental PsychologyAuthor(s): Emmy van Esch, Robert Minjock, Stephen M. Colarelli, Steven HirschAbstractA growing number of organizations are re-designing workplaces to give employees greater exposure to natural views, which frequently improve well-being. But what is it about views of nature that produce these benefits? Is it the overall view or the particular features within a view? If it is features, what features have the greatest effects on well-being, and are these features particular to natural settings or might they generalize to built settings? W...
Source: Journal of Environmental Psychology - Category: Psychiatry & Psychology Source Type: research
Thirty-two people tested positive for the flu, the U.S. Border Patrol said
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Conclusions: Glucose fluctuation aggravates mesangial cell apoptosis, which may be partly induced by activating oxidative stress and inhibiting the AKT signaling pathway. PMID: 31110541 [PubMed]
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
Conclusions: For patients with early axSpA in remission on YSP for more than 12 weeks, continuation of YSP at full dose was superior to discontinuation of YSP, but not superior to halving the dose. PMID: 31110537 [PubMed]
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
Conclusions: Alcohol septal ablation was safe and effective in the long-term follow-up. We observed a reduced life expectancy compared to the age- and sex-matched general population. Mortality was almost equally due to cardiovascular and non-cardiovascular causes of death. PMID: 31110530 [PubMed]
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
Authors: Grzelak T, Wedrychowicz A, Grupinska J, Pelczynska M, Sperling M, Mikulska AA, Naughton V, Czyzewska K Abstract Introduction: The aim of our study was to determine the relationship between neuropeptide B (NPB), neuropeptide W (NPW), nutritional and antioxidant status and selected fat- and bone-derived factors in type 1 diabetes mellitus (T1DM) treated using pens (T1DM pen group) or insulin pumps (T1DM pump group) in order to investigate the potential role of NPB and NPW in the clinical outcomes of T1DM. Material and methods: Fifty-eight patients with T1DM and twenty-five healthy controls (CONTR) partic...
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
Authors: Wierzba W, Pinkas J, Karnafel W, Dziemidok P, JawieΕ„ A, Śliwczynski A Abstract Introduction: There are reports that diabetes mellitus reduces the risk of aortic aneurysms and many reports that diabetes mellitus reduces the risk of abdominal aortic aneurysms. In earlier years there were also studies that did not demonstrate any effects of diabetes on the rate of aortic aneurysms. Material and methods: For the year 2012, between 1 January and 31 December, reports for services regarding treatment for aortic aneurysms were found. At the same time, the reports for services associated with diabetes with th...
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
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