Gilead teams with startup to turn machine learning on fatty liver disease

Even before much of the world last year found out about Daphne Koller's machine-learning-driven drug development company, she was invited to speak to Gilead Sciences Inc. scientists. The ensuing conversations have led Koller's Insitro to formally work with Gilead to find new targets for drugs to attack one of the hottest areas in drug development. The companies disclosed the three-year deal Tuesday morning. Insitro will receive $15 million upfront, plus "near-term" milestone payments up to $35 million…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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ConclusionExperimental validation of network analysis revealed anti-diabetic effects of the plant product SGD, manifested most notably by improved serum profiles and diminished insulin resistance. These experimental results may have clinical implications.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Condition:   Non-alcoholic Steatohepatitis Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide) Sponsor:   Novo Nordisk A/S Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Saroglitazar, a novel dual peroxisome proliferator activated receptor (PPAR) agonist, in clinical trials, has shown an improvement in lipid and glycemic parameters through the PPAR- α and γ agonist actions, res...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Review Source Type: research
Publication date: Available online 15 June 2019Source: MicronAuthor(s): M. Rusaczonek, B. Zapotoczny, M. Szymonski, J. KoniorAbstractElasticity of biological systems is considered to be an important property that might be related to functional or pathological changes. Therefore, careful study and detailed understanding of cell and tissue elasticity is crucial for correct description of their functioning. Atomic force microscopy (AFM) is a powerful technique, which allows for determination of the physical properties, such as elasticity, of soft-matter systems in nano-scale. An important step in AFM elasticity studies is a p...
Source: Micron - Category: Biology Source Type: research
ConclusionIt seems that omega-3 consumption along with severe interval exercise is an effective factor in preventing from and improving cardiovascular risk factors and fatty liver in young inactive men since the regimen increases lipid metabolism due to the desirable effects on liver enzymes, lipid profile, and body composition.RésuméIntroductionIl est important d’évaluer l’effet des activités sportives sur les enzymes hépatiques afin de déterminer leur action préventive sur les pathologies hépatiques. Cette recherche a pour but d’apprécier l&...
Source: Science and Sports - Category: Sports Medicine Source Type: research
Insulin resistance (IR) related metabolic disorders are associated with a worse prognosis of chronic hepatitis B virus (CHB) infection or nonalcoholic fatty liver disease (NAFLD). However, the relationships am...
Source: Diabetology and Metabolic Syndrome - Category: Endocrinology Authors: Tags: Research Source Type: research
This study analyzed 15 randomized, controlled trials involving 782 patients with NAFLD. Probiotics and synbiotics supplementation could significantly improve liver steatosis, alanine aminotransferase, aspartate aminotransferase, triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein, homeostasis model assessment-insulin resistance, liver stiffness and tumor necrosis factor-alpha (allP  
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Authors: Li AA, Ahmed A, Kim D Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and encompasses a spectrum of pathology from simple steatosis to inflammation and significant fibrosis that leads to cirrhosis. NAFLD and its comorbid conditions extend well beyond the liver. It is a multisystemic clinical disease entity with extrahepatic manifestations such as cardiovascular disease, type 2 diabetes, chronic kidney disease, hypothyroidism, polycystic ovarian syndrome, and psoriasis. Indeed, the most common causes of mortality in subjects with NAFLD are cardiovascular disease, f...
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research
ConclusionIn individuals with diabetes and NAFLD, PNPLA3 gene rs738409 C>G polymorphism is a risk marker for significant liver fibrosis and cardiovascular disease and may be associated with better glycemic control.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Conditions:   Nonalcoholic Fatty Liver;   Metabolic Syndrome Intervention:   Sponsor:   Hippocration General Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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