Diabetes and Hypertension Differentially Affect Renal Catecholamines and Renal Reactive Oxygen Species
Conclusion
In this study we describe specific differences between diabetic mice with and without concomitant hypertension. In particular we demonstrate renal cortical levels of dopamine and norepinephrine were greatest in non-diabetic hypertensive mice whilst diabetes was associated with significantly lower levels of both these catecholamines. Diabetic mice with concomitant hypertension retain elevations in renal dopamine and norepinephrine levels although to a significantly reduced extent compared to non-diabetic hypertensive animals. Hypertension per se was not associated with albuminuria or renal damage at this time point however diabetic hypertensive mice displayed overt albuminuria. These data suggest diabetic mice with concomitant hypertension are particularly prone to oxidative stress in part due to increased catecholamine metabolism by MAO-A as well as reduced anti-oxidant capacity. Neither the renal catecholaminergic system, nor renal oxidative stress are current clinical priorities in patients with diabetes and concomitant hypertension. These findings suggest that oxidant and antioxidant systems should be approached as potential clinical targets, particularly in patients with concomitant diabetes and hypertension.
Author Contributions
AW designed and performed the experiments, analyzed and collated the data, and wrote the manuscript. AW is responsible and accountable for all data presented, including the integrity of the data and the accuracy of the data analysis...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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