Broadening the Debate About Post-trial Access to Medical Interventions: A Qualitative Study of Participant Experiences at the End of a Trial Investigating a Medical Device to Support Type 1 Diabetes Self-Management.

Broadening the Debate About Post-trial Access to Medical Interventions: A Qualitative Study of Participant Experiences at the End of a Trial Investigating a Medical Device to Support Type 1 Diabetes Self-Management. AJOB Empir Bioeth. 2019 Apr 15;:1-13 Authors: Lawton J, Blackburn M, Rankin D, Werner C, Farrington C, Hovorka R, Hallowell N Abstract Increasing ethical attention and debate is focusing on whether individuals who take part in clinical trials should be given access to post-trial care. However, the main focus of this debate has been upon drug trials undertaken in low-income settings. To broaden this debate, we report findings from interviews with individuals (n = 24) who participated in a clinical trial of a closed-loop system, which is a medical device under development for people with type 1 diabetes that automatically adjusts blood glucose to help keep it within clinically recommended ranges. Individuals were recruited from UK sites and interviewed following trial close-out, at which point the closed-loop had been withdrawn. While individuals were stoical and accepting of the requirement to return the closed-loop, they also conveyed varying degrees of distress. Many described having relaxed diabetes management practices while using the closed-loop and having become deskilled as a consequence, which made reverting back to pre-trial regimens challenging. Participants also described unanticipated consequences arising from using a ...
Source: AJOB Primary Research - Category: Medical Ethics Tags: AJOB Empir Bioeth Source Type: research

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Authors: Grzelak T, Wedrychowicz A, Grupinska J, Pelczynska M, Sperling M, Mikulska AA, Naughton V, Czyzewska K Abstract Introduction: The aim of our study was to determine the relationship between neuropeptide B (NPB), neuropeptide W (NPW), nutritional and antioxidant status and selected fat- and bone-derived factors in type 1 diabetes mellitus (T1DM) treated using pens (T1DM pen group) or insulin pumps (T1DM pump group) in order to investigate the potential role of NPB and NPW in the clinical outcomes of T1DM. Material and methods: Fifty-eight patients with T1DM and twenty-five healthy controls (CONTR) partic...
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
Researchers say there may be triggers to the genetically linked type 1 diabetes, finding in a recent study that coxsackievirus may be one of those triggers.
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This study examined the associations between risk of ASD in offspring and maternal T1D, T2D, and GDM.
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Source: Cell Reports - Category: Cytology Source Type: research
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Source: Cell Reports - Category: Cytology Source Type: research
In this study, we found that AMPK activator metformin suppresses T cell proliferation and inhibits the differentiation of Th1 and Th17 cells while promoting the development of Tregs in vitro in a dose-dependent manner. Treatment of NOD mice with metformin significantly mitigated autoimmune insulitis and substantially decreased the number of pro-inflammatory IFN-γ+ as well as IL17+ CD4 T cells in the spleens of NOD mice. However, a significantly increased percentage of regulatory IL-10+ and Foxp3+ CD4 T cells were seen. We provided a novel potential therapeutic method--by regulating T cell metabolism through targeting...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
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Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
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Source: Acta Diabetologica - Category: Endocrinology Source Type: research
ConclusionsThis exploratory study highlighted the significance of a cohesive family context to facilitate the achievement of individual glycaemic goals in individuals with T1D. These observations, if confirmed in larger data sets, would timely call for a comprehensive family care assessment as part of the evaluations routinely carried out in the ambulatory care of these individuals.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
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