Diastereo- and enantioselective palladium-catalyzed dearomative [4+2] cycloaddition of 3-nitroindoles

Publication date: Available online 16 April 2019Source: Chinese Chemical LettersAuthor(s): Jia-Jia Suo, Juan Du, Yang-Jie Jiang, Di Chen, Chang-Hua Ding, Xue-Long HouAbstractA Pd-catalyzed asymmetric decarboxylative [4 + 2] cycloaddition of 3-nitroindoles and vinyl benzoxazinanones is developed through a dearomatization approach. The reaction provides an efficient protocol for constructing a series of chiral tetrahydro-5H-indolo[2,3-b]quinolines in high yields and with excellent diastereo- and enantioselectivities.Graphical abstractReviewed herein is the recent progress of the first-row transition metals catalyzed C-H functionalization reactions with allenes until the end of 2018. This review is organized by the pivotal metal complexes which catalyze the sp2 C-H bond cleavage.

Source: Chinese Chemical Letters - April 16, 2019 Category: Chemistry Source Type: research