Falling for a scam may be an early warning sign of dementia, a new study suggests 

Older Americans lose about $35 billion collectively a year to scammers. Those with poor con-radar are at about a two-fold risk of dementia, Rush University research suggests.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Authors: Śmigórska A, Śmigórski K, Rymaszewska J Abstract The following article discusses the possibility of applying a rehabilitation strategy known as Errorless Learning (EL) in patients suffering from Alzheimer's disease (AD). The authors present the issue in the context of the knowledge on the effectiveness of administering neuropsychological interventions in patients with AD. The history of the EL method development is presented as well as techniques used in its domain. The novelty of the EL methodological approach is shown. It is emphasized that EL, in contrast with the majority of neuropsycho...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
CONCLUSIONS: These results are especially relevant when compared to previous SSD studies showing effects in behavior only after a demanding cognitive training. We discuss the implications of our results for development of SSDs and of specific rehabilitation programs for the hearing impaired either using or not using HAs or CIs. We also discuss the potential application of such a set-up for sense augmentation, such as when learning a new language. PMID: 31006700 [PubMed - in process]
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research
Conditions:   Mild Cognitive Impairment;   Alzheimer Dementia Intervention:   Behavioral: Supervised Exercise Programme Sponsors:   University of Cadiz;   Centro de Excelencia en Metabolómica y Bioanálisis (CEMBIO);   Servicio Central de Neuroimagen de la Universidad Pablo de Olavide;   Consejería de Salud y Bienestar Social, Andalucía Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 23 April 2019Source: Alzheimer's &DementiaAuthor(s): Mélanie Fortier, Christian-Alexandre Castellano, Etienne Croteau, Francis Langlois, Christian Bocti, Valérie St-Pierre, Camille Vandenberghe, Michaël Bernier, Maggie Roy, Maxime Descoteaux, Kevin Whittingstall, Martin Lepage, Éric E. Turcotte, Tamas Fulop, Stephen C. CunnaneAbstractIntroductionUnlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Researchers here report on discovering that an existing farnesyltransferase inhibitor drug reverses the accumulation of altered tau protein aggregates in a mouse model. The death and dysfunction of nerve cells in the neurodegenerative conditions known as tauopathies is driven by the formation of neurofibrillary tangles, made of tau protein. That in turn has deeper causes, such as the chronic inflammation produced by senescent cells and disruption of immune cell activity in the central nervous system, one of which is no doubt being adjusted in some way by the action of the drug in this case. As in all such quite indirect me...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
While clearing out amyloid-β from the brain has so far proven to be a matter of too little, too late in late stage Alzheimer's disease patients, there is still a strong basis of evidence for the merits of removing amyloid-β. It is reasonable to say that it causes meaningful pathology; if people did not accumulate amyloid-β deposits, then there would be no consequent disarray in the function of neurons and immune cells in the brain. This particular foundation of the development of dementia would be removed. Even if the mechanisms of the later stages of Alzheimer's, the chronic inflammation and tau protein agg...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Contributors : Erin McKay ; John Beck ; Mary Winn ; Karl Dykema ; Andrew Lieberman ; Henry Paulson ; Scott CountsSeries Type : Expression profiling by arrayOrganism : Homo sapiensGene expression profiling was performed on frontal and temporal cortex from vascular dementia (VaD), Alzheimer's disease (AD), and non-demented controls (Control) obtained from the University of Michigan Brain Bank. Controls and AD cases had no infarcts in the autopsied hemisphere. Vascular dementia cases had low Braak staging.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
In conclusion, our data confirm t-α-synuclein and p-α-synuclein as robust biomarkers for sCJD and indicate the potential use of col orimetric t-α-synuclein ELISAs for differential diagnosis of dementia types.
Source: Molecular Neurobiology - Category: Neurology Source Type: research
In conclusion, insular sub-regional atrophy, particularly the anterior dorsal region, may contribute to cognitive and neuropsychiatric deficits in neurodegeneration. Our results support anterior insular cortex vulnerability and convey the differential involvement of th e insular sub-regions in functional deficits in neurodegenerative diseases.
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research
AbstractDespite significant advancements in the field of molecular neurobiology especially neuroinflammation and neurodegeneration, the highly complex molecular mechanisms underlying neurodegenerative diseases remain elusive. As a result, the development of the next generation neurotherapeutics has experienced a considerable lag phase. Recent advancements in the field of genome editing offer a new template for dissecting the precise molecular pathways underlying the complex neurodegenerative disorders. We believe that the innovative genome and transcriptome editing strategies offer an excellent opportunity to decipher nove...
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research
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