Why ARE so many non-smokers dying of lung cancer?

Cases from lung cancer in non-smokers have doubled in the past seven years, and appears to be more common in women according to research from patients at the Royal Brompton Hospital.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Abstract Fisetin (3,3',4',7-tetrahydroxyflavone) is a bioactive polyphenolic flavonoid found in many fruits and vegetables. It exhibits a variety of pharmacological activities including anticancer and anti-invasive effects. Epithelial to mesenchymal transition (EMT) allows the tumor cells to acquire increased migratory and invasive properties mediating their dissemination to faraway sites, thus favoring metastasis. With metastatic lung cancer claiming the majority of lung cancer-related deaths, agents targeting the pathways underlying metastasis are translationally promising. In the present study, we have explored...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
Conclusion: MIR4435-2HG is upregulated in HCC and promotes cancer cell proliferation possibly by upregulating miRNA-487a. PMID: 30988676 [PubMed - in process]
Source: Cellular and Molecular Biology Letters - Category: Biochemistry Authors: Tags: Cell Mol Biol Lett Source Type: research
Condition:   Lung Cancer Intervention:   Behavioral: Home rehabilitation exercise program Sponsors:   National Taipei University of Nursing and Health Sciences;   Ministry of Science and Technology, Taiwan;   National Taiwan University Hospital;   Mackay Memorial Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Medicaid coverage for lung cancer screening is highly variable among states and even within the same state, according to a new report.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Publication date: Available online 16 April 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Xue Ma, Wenrui Du, Yan Li, Chenfeng Hua, Ajuan Yu, Wuduo Zhao, Shusheng Zhang, Fuwei XieABSTRACTTwo novel sorbents based on polydopamine (PDA)-coated magnetic graphite oxide-metal organic frameworks nanoparticles [Cu(L-mal)(bpy)]·H2O (MGO-CuLBH) and [Cu(D-mal)(bpy)]·H2O (MGO-CuDBH) possessing of both magnetic property and excellent enantioselective ability were prepared and characterized. Solutions of racemic propranolol hydrochloride (Rac-PRO) were chosen to investigate the enantioselective per...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
Conclusion: Our findings of immunotherapy treatment outside clinical trials support the results of studies in the past and confirm the efficacy and favorable toxicity profile of nivolumab treatment in advanced SQ-NSCLC patients. In addition, we can present some rarely described information about nivolumab treatment of heavily pretreated patients, which provides some evidence that immunotherapy could also be useful in later therapy lines.Oncol Res Treat
Source: Oncology Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionThese findings revealed a novel pharmacological action and the underlying mechanism of lusianthridin in negatively regulating CSC-like phenotypes and sensitizing resistant cancer cells to cemetery.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
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Source: Drug and Chemical Toxicology - Category: Toxicology Authors: Source Type: research
In this study, we treated egg-laying hens with DA, screened for key mRNAs and lncRNAs related to immune regulation using transcriptome technology, and performed cell experiments to explore the specific molecular biological mechanisms underlying the regulation of immune responses by lncRNAs. Materials and Methods Materials The DA used in this study was synthetically produced by the Kai Meng Co. (Xi An, Shanxi, China) Chemical Plant with a purity of 99.9%. Feeding Experimental Design and Bird Management The experimental animal procedures were approved by the China Agricultural University Animal Care and Use Committee (B...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Ivana Bjelobaba1,2, Marija M. Janjic1,2, Rafael Maso Prévide1, Daniel Abebe1, Marek Kucka1 and Stanko S. Stojilkovic1* 1Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, MD, United States 2Institute for Biological Research Sinisa Stankovic, University of Belgrade, Belgrade, Serbia Cell-matrix interactions play important roles in pituitary development, physiology, and pathogenesis. In other tissues, a family of non-collagenous proteins, termed SIBLINGs, are known to contribute to cell-matrix interactions. Anterior pituitary gland...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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