Two cases of diabetes mellitus type 1 after alemtuzumab treatment for multiple sclerosis: another probable secondary autoimmune disease

Source: Journal of Neurology - Category: Neurology Source Type: research

Related Links:

Hugo Barcenilla1*†, Linda Åkerman1†, Mikael Pihl2, Johnny Ludvigsson1,3 and Rosaura Casas1 1Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden 2Core Facility, Flow Cytometry Unit, Linköping University, Linköping, Sweden 3Crown Princess Victoria Children's Hospital, Region Östergötland, Linköping, Sweden Type 1 diabetes (T1D) is characterized by autoimmune destruction of insulin producing β-cells. The time from onset of islet autoimmunity to m...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Maunil K. Desai1 and Roberta Diaz Brinton2,3* 1School of Pharmacy, University of Southern California, Los Angeles, CA, United States 2Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States 3Departments of Pharmacology and Neurology, College of Medicine, University of Arizona, Tucson, AZ, United States Women have a higher incidence and prevalence of autoimmune diseases than men, and 85% or more patients of multiple autoimmune diseases are female. Women undergo sweeping endocrinological changes at least twice during their lifetime, puberty and menopause, with many women undergoin...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Suzan Wetzels1,2, Tim Vanmierlo2,3, Jean L. J. M. Scheijen1, Jack van Horssen4, Sandra Amor5, Veerle Somers2, Casper G. Schalkwijk1, Jerome J. A. Hendriks2† and Kristiaan Wouters1*† 1Cardiovascular Research Institute Maastricht, Department of Internal Medicine, Maastricht University, Maastricht, Netherlands 2Biomedical Research Institute, Department of Immunology and Biochemistry, Hasselt University, Hasselt, Belgium 3Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands 4Department of Molecular Cell Biology and Immuno...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CD4+ T-Cells With High Common γ Chain Expression and Disturbed Cytokine Production Are Enriched in Children With Type-1 Diabetes Julia Seyfarth1*, Nathalie Mütze1, Jennifer Antony Cruz1, Sebastian Kummer1, Christina Reinauer1, Ertan Mayatepek1, Thomas Meissner1,2 and Marc Jacobsen1 1Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital, Medical Faculty, Düsseldorf, Germany 2German Center for Diabetes Research (DZD), Partner Düsseldorf, Düsseldorf, Germany The common gamma chain (γc) contributes to the formation of different c...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 5 April 2019Source: Autoimmunity ReviewsAuthor(s): Chan-Na Zhao, Zhiwei Xu, Guo-Cui Wu, Yan-Mei Mao, Li-Na Liu, Qian-Wu, Yi-Lin Dan, Sha-Sha Tao, Qin Zhang, Napoleon Bellua Sam, Yin-Guang Fan, Yan-Feng Zou, Dong-Qing Ye, Hai-Feng PanAbstractAutoimmune diseases (ADs) are a broad spectrum of disorders featured by the body's immune responses being directed against its own tissues, resulting in prolonged inflammation and subsequent tissue damage. Recently, the exposure to ambient air pollution has been implicated in the occurrence and development of ADs. Mechanisms linking air pollution expos...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Conclusion Familial associations with several autoimmune diseases suggest genetic sharing and challenge to gene identification.
Source: Psychiatric Genetics - Category: Genetics & Stem Cells Tags: ORIGINAL ARTICLES Source Type: research
Publication date: Available online 5 December 2018Source: SeizureAuthor(s): Man Amanat, Roland Thijs, Mona Salehi, Josemir W. SanderAbstractThe risk of epileptic seizures seems increased in several systemic autoimmune disorders including systemic lupus erythematosus, type 1 diabetes mellitus, myasthenia gravis, celiac disease, rheumatoid arthritis, Hashimoto’s encephalopathy, psoriasis, multiple sclerosis, neuromyelitis optica, and bullous pemphigoid. Immune dysfunction may be partly responsible for this association. Elevated levels of pro-inflammatory cytokines, autoantibodies seen in these autoimmune disorders and ...
Source: Seizure - Category: Neurology Source Type: research
Conclusions: Despite routine use of alemtuzumab, clinical presentations of AITD seem to be uncommon in CIT patients receiving immunosuppression. However, AITD can develop following withdrawal of immunosuppression, highlighting the need for careful thyroid surveillance in this population. PMID: 30398662 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Autoimmune diseases commonly affect women of childbearing age, yet the risk of adverse pregnancy outcomes among women with autoimmune disease is underexamined. We hypothesized pregnancies complicated by Type 1 diabetes mellitus (T1DM), systemic lupus erythematosus (SLE) Crohn ’s disease, multiple sclerosis (MS) or rheumatoid arthritis (RA) would have increased risk of preeclampsia, preterm birth (PTB), small for gestational age (SGA), respiratory distress syndrome (RDS), and neonatal intensive care (NICU) admission.
Source: Annals of Epidemiology - Category: Epidemiology Authors: Source Type: research
More News: Autoimmune Disease | Brain | Diabetes | Diabetes Mellitus | Diabetes Type 1 | Endocrinology | Multiple Sclerosis | Neurology