SV40 seroprevalence in two Latin American countries involved in field trials of candidate oral poliovaccines

Polyomavirus simian virus 40 (SV40) has been reported to cause infections in humans, although the prevalence and distribution of such infections are unknown. The natural host for SV40 is the rhesus macaque and the origin of cross-species human infections dates from 1954 and the use of contaminated poliovaccines.1,2 Vaccine lots of both inactivated (IPV) and live attenuated oral (OPV) poliovaccine were potentially contaminated before the discovery of SV40 in 1960. The virus was an unrecognized agent present in many of the primary rhesus monkey kidney cell cultures used for vaccine production.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research