A Multi-Centered Case-Case-Control Study of Factors Associated With Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae Infections in Children and Young Adults

Conclusions: Pediatric patients with KPC-CRE infection suffer from high multi-system disease/device burdens and exposures to carbapenems and aminoglycosides. Different from adult reports, non-ST258 KP strains were more common, and LOS and mortality rates were similar in all groups. Pediatric CRE control in should focus on modifiable risk factors including antibiotic and device utilization.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research

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Conclusions: The strong association of infection with MDR organisms showing FQR with patient residence rather than with traditional risk factors suggests that the community environment is a major contributor to spread of these pathogens in children.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research
Drug-resistance dissemination by horizontal gene transfer remains poorly understood at the cellular scale. Using live-cell microscopy, we reveal the dynamics of resistance acquisition by transfer of the Escherichia coli fertility factor–conjugation plasmid encoding the tetracycline-efflux pump TetA. The entry of the single-stranded DNA plasmid into the recipient cell is rapidly followed by complementary-strand synthesis, plasmid-gene expression, and production of TetA. In the presence of translation-inhibiting antibiotics, resistance acquisition depends on the AcrAB-TolC multidrug efflux pump, because it reduces tetr...
Source: ScienceNOW - Category: Science Authors: Tags: Cell Biology, Microbiology reports Source Type: news
ConclusionThis is the first draft genome sequence of an E. coli ST189 isolate serotype O80:H26-fimH54 obtained from soil. This draft genome sequence can be used to compare antimicrobial resistant E. coli isolates obtained from different sources.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Avian pathogenic Escherichia coli (APEC) is the principle cause of colibacillosis affecting poultry. The main challenge to the poultry industry is antimicrobial resistance and the emergence of multidrug resistant...
Source: BMC Veterinary Research - Category: Veterinary Research Authors: Tags: Research article Source Type: research
Veening Here, we describe the creation of three integration vectors, pPEPX, pPEPY and pPEPZ, for use with the opportunistic human pathogen Streptococcus pneumoniae. The constructed vectors, named PEP for Pneumococcal Engineering Platform (PEP), employ an IPTG-inducible promoter and BglBrick and BglFusion compatible multiple cloning sites allowing for fast and interchangeable cloning. PEP plasmids replicate in Escherichia coli and harbor integration sites that have homology in a large set of pneumococcal strains, including recent clinical isolates. In addition, several options of antibiotic resistance markers are avail...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Conclusion The marked metabolic differences in de novo lipogenesis and glycolysis in [18F]FDG and [18F]FAC uptakes in micro-PET imaging, respectively, help to differentiate chronic TB infection from acute infection.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research
ConclusionsAntibiotic resistance was extremely severe inE. coli LCT-EC001, mainly due to mobile genetic elements that allowed the gain of a large quantity of resistance genes. The antibiotic resistance genes ofE. coli LCT-EC001 can probably be transferred to other bacteria. To the best of our knowledge, this is the first report of a strain ofE. coli which has such a large amount of antibiotic resistance genes. Apart from providing anE. coli reference genome with an extremely high multidrug-resistant background for future analyses, this work also offers a strategy for investigating the complement and characteristics of gene...
Source: Gut Pathogens - Category: Microbiology Source Type: research
Foodborne Pathogens and Disease, Ahead of Print.
Source: Foodborne Pathogens and Disease - Category: Food Science Authors: Source Type: research
ConclusionsThe co-existence of the mcr-1 and ESBL/AmpC genes and the very high level of multiple drug resistance in all colistin resistant E. coli isolates obtained from sampled chicken farms in Vietnam is a major concern.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionsThis study reports ESBL-producing Enterobacteriaceae in Tunisian camels from both touristic and meat-producing sectors. This is also the first description of the mcr-1 gene in a meat-producing camel. Though not alarming, this context needs specific attention to avoid that camels become a bigger reservoir of multidrug-resistant Enterobacteriaceae.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
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