Influenza Cataclysm, 1918

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Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Current Abstracts Source Type: research

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(Taylor&Francis Group) The most severe pandemic in recent history, killing some 50 million people worldwide, the Spanish influenza, may have emerged up to two years earlier than previously believed. And, according to a new and influential study, its early manifestation was ignored at the time as a 'minor infection.'
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
The multifunctional influenza virus protein PB1-F2 plays several roles in deregulation of host innate immune responses and is a known immunopathology enhancer of the 1918 influenza pandemic. Here, we show that the 1918 PB1-F2 protein not only interferes with the mitochondria-dependent pathway of type I interferon (IFN) signaling, but also acquired a novel IFN antagonist function by targeting the DEAD-box helicase DDX3, a key downstream mediator in antiviral interferon signaling, toward proteasome-dependent degradation. Interactome analysis revealed that 1918 PB1-F2, but not PR8 PB1-F2, binds to DDX3 and causes its co-degra...
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Immunology, Microbiology, Virology & Host Pathogen Interaction Articles Source Type: research
Viruses, Vol. 11, Pages 433: What’s New with Flu? An Overview Viruses doi: 10.3390/v11050433 Authors: Seema S. Lakdawala Christopher B. Brooke One hundred years have passed since the 1918 H1N1 pandemic, and influenza viruses continue to pose an enormous and unpredictable global public health threat [...]
Source: Viruses - Category: Virology Authors: Tags: Editorial Source Type: research
Publication date: Available online 4 May 2019Source: Journal of Theoretical BiologyAuthor(s): Jasmina Panovska-Griffiths, Luca Grieco, Edwin van Leeuwen, Marc Baguelin, Richard Pebody, Martin UtleyAbstractIn the event of a novel influenza strain that is markedly different to the current strains circulating in humans, the population have little/no immunity and infection spreads quickly causing a global pandemic. Over the past century, there have been four major influenza pandemics: the 1918 pandemic (“Spanish Flu”), the 1957-58 pandemic (the “Asian Flu”), the 1967-68 pandemic (the “Hong Kong Fl...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Mireia Pedragosa1†, Graciela Riera1†, Valentina Casella1, Anna Esteve-Codina2,3, Yael Steuerman4, Celina Seth1, Gennady Bocharov5,6, Simon Heath2,3, Irit Gat-Viks4, Jordi Argilaguet1* and Andreas Meyerhans1,7* 1Infection Biology Laboratory, Department of Experimental and Health Sciences (DCEXS), Universitat Pompeu Fabra, Barcelona, Spain 2CNAG-CRG, Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain 3Universitat Pompeu Fabra, Barcelona, Spain 4Cell Research and Immunology Department, Tel Aviv University, Tel Aviv, Israel 5Marchuk Institute of Numeric...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Mark K. Slifka1* and Ian J. Amanna2 1Division of Neuroscience, Oregon National Primate Research Center, Oregon Health &Science University, Beaverton, OR, United States2Najít Technologies, Inc., Beaverton, OR, United States Vaccines play a vital role in protecting our communities against infectious disease. Unfortunately, some vaccines provide only partial protection or in some cases vaccine-mediated immunity may wane rapidly, resulting in either increased susceptibility to that disease or a requirement for more booster vaccinations in order to maintain immunity above a protective level. The durability of a...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Abstract Disparities in cross-city pandemic severity during the 1918 Influenza Pandemic remain poorly understood. This paper uses newly assembled historical data on annual mortality across 438 U.S. cities to explore the determinants of pandemic mortality. We assess the role of three broad factors: i) pre-pandemic population health and poverty, ii) air pollution, and iii) the timing of onset and proximity to military bases. Using regression analysis, we find that cities in the top tercile of the distribution of pre-pandemic infant mortality had 21 excess deaths per 10,000 residents in 1918 relative to cities in the...
Source: Economics and Human Biology - Category: Biology Authors: Tags: Econ Hum Biol Source Type: research
[La encefalitis letárgica de von Economo y la pandemia de la gripe española en Bogotá y Medellín: reseña histórica cien años después]. Biomedica. 2019 Mar 31;39(1):8-16 Authors: Uribe CS, González AL, González P Abstract La encefalitis letárgica de von Economo es un trastorno neuropsiquiátrico de posible origen autoinmunitario, en el cual se afectan los ganglios basales. Esta reacción puede ocurrir luego de una infección aguda por diversos agentes virales o bacterianos. Dado que aparece cuando ya se ha res...
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
In conclusion, the reported results highlight the importance of AIV attachment to trachea in many avian species. Finally, the importance of chickens and mallards in AIVs dynamics was illustrated by the abundant AIV attachment observed. Introduction Influenza A viruses (IAVs) are pathogens of global concern in both human and veterinary medicine (Webster et al., 1992; Stöhr, 2002; Olsen et al., 2006; Wiethoelter et al., 2015). Wild birds are well-described hosts of avian influenza viruses (AIVs) and longitudinal surveillance studies have demonstrated a plethora of low pathogenic AIVs (LPAIVs) circulating in wild...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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