High-fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett ’s Esophagus via IL8 and Alterations to the Gut Microbiome

Barrett ’s esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Progression from BE to cancer is associated with obesity, possibly due to increased abdominal pressure and gastroesophageal reflux disease, although this pathogenic mechanism has not been proven. We investigated whether environme ntal or dietary factors associated with obesity contribute to progression of BE to EAC in mice.

Source: Gastroenterology - April 14, 2019 Category: Gastroenterology Authors: Natasha Stephens M ünch, Hsin-Yu Fang, Jonas Ingermann, H. Carlo Maurer, Akanksha Anand, Victoria Kellner, Vincenz Sahm, Maria Wiethaler, Theresa Baumeister, Frederik Wein, Henrik Einwächter, Florian Bolze, Martin Klingenspor, Dirk Haller, Maria Kavanag Source Type: research