Editorial: Thyroid Hormone and Metabolites: Central Versus Peripheral Effects

Editorial: Thyroid Hormone and Metabolites: Central Versus Peripheral Effects Grazia Chiellini1, Federica Cioffi2, Rosalba Senese3 and Pieter de Lange3* 1Dipartimento di Patologia Chirurgica, Medica, Molecolare e dell'Area Critica, Università degli Studi di Pisa, Pisa, Italy 2Dipartimento di Scienze e Tecnologie, Università degli Studi del Sannio, Benevento, Italy 3Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Università degli Studi della Campania “Luigi Vanvitelli”, Caserta, Italy Editorial on the Research Topic Thyroid Hormone and Metabolites: Central Versus Peripheral Effects The organism's metabolic state is under tight control and an efficient balance between glucose and lipid metabolism is crucial for maintenance of energy homeostasis, which allows the body to function optimally. Metabolic homeostasis is under control of hormones as well as the sympathetic/parasympathetic nervous systems. Particularly thyroid hormone (TH) plays an important role in the regulation of energy expenditure. The action of metabolically active TH metabolites involves a plethora of avenues which have been and are still being unraveled from the previous century to the present day. At the cellular level, the classic, biologically active TH, 3,5,3′-triiodo-L-thyronine (T3), predominantly acts through thyroid hormone receptors (THRs), which are predominantly localized in the nucleu...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research