Identification of Genetic Mutations in Cancer: Challenge and Opportunity in the New Era of Targeted Therapy

Conclusions In the new era of targeted therapy, treatment options are increasingly based on the precise molecular and genetic profiling of tumor cells (58). Currently, the main challenge for further novel drug development in targeted therapy is the clarification of specific molecular mechanisms underlying the varied forms of tumors in clinic. It has been acknowledged that cancer is caused by a set of driver mutations. In this regard, it is of great significance to: (1) identify and validate key mutant genes and proteins in cancers as new targets; (2) identify patients most likely and unlikely to benefit from certain targeted therapies; (3) evaluate the mechanism of mutation-driven drug resistance. In past decades, several key mutations which influence drug sensitivity have been identified in various cancers. In order to deal with mutation-driven drug resistance, new methods and drugs have been discovered and approved for clinical use (47). Even so, detailed individualized treatment strategies targeting specific tumorigenesis and drug resistant mechanisms are still required. Advances in these areas would allow for more targeted and effective therapeutic options for more cancer patients. Author Contributions ML, JS, JL, YZ, JW, LQ, and QW were responsible for the review of the literature. JJ, JY, XW, QZ, CC, and ML wrote the manuscript. XW and LQ drew the Tables. XW, TY, and ZX designed the study and contributed with the valuable discussion and revision of the manuscript. F...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Source: Headlines - Category: Radiology Source Type: news
ConclusionPhenobarbital and sodium valproate were proven to be efficacious in treating convulsive epilepsy in rural northeast China. The patients’ compliance still needs to be improved.
Source: Seizure - Category: Neurology Source Type: research
This study examined postgraduates' personal digital archiving (PDA) practices in China. Based on a case study of the PDA practices of postgraduates in Wuhan University, many problems in PDA were found; postgraduates have a higher awareness of PDA, but the differences between different grades level and disciplines are obvious. Many postgraduates are technological optimists. Those who realize the importance of PDA lack real action and can only use a single strategy. The protection of personal privacy and information security is still challenging. To solve these problems, efforts from individuals and institutions are proposed...
Source: The Journal of Academic Librarianship - Category: Databases & Libraries Source Type: research
Conclusions: Due to the complexity of the behavior and biology of cells, scientists' primary focus should be on detection and elimination of sources of inflammation. Antiparasitic medications, and also antiviral, antibiotic, and antifungal medications should be thought of as underrecognized, underappreciated, and forgotten medications that can be part of cancer therapy. The information offered in this review suggests scientists should think of cancer not only as a metabolic disease but also as a metabolic parasite and should consider using antiparasitic medications under a new understanding of the role of inflammation, inf...
Source: Alternative Therapies in Health and Medicine - Category: Complementary Medicine Authors: Tags: Altern Ther Health Med Source Type: research
Conclusions: While case reports cannot be considered as proof of efficacy, these cases added to others of patients treated with the same method would suggest that this is a viable option for those patients whose disease cannot be treated successfully with other modalities. PMID: 31202206 [PubMed - in process]
Source: Alternative Therapies in Health and Medicine - Category: Complementary Medicine Authors: Tags: Altern Ther Health Med Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Publication date: Available online 15 June 2019Source: Seminars in Cancer BiologyAuthor(s): Michael Timaner, Kelvin Tsai, Yuval ShakedAbstractMesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epit...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: August 2019Source: Cancer Epidemiology, Volume 61Author(s): Ryan Wendt, Yubo Gao, Benjamin J. MillerAbstractBackgroundThere is an undefined relationship between access to regional referral centers and whether the eventual oncologic outcomes are influenced by distance, travel time, or residence in a rural community.MethodsWe used the Surveillance, Epidemiology and End Results (SEER) Program Database to capture all cases of high-grade osteosarcoma from 1990 to 2014 in Iowa, Utah, and New Mexico. Using univariate, Kaplan Meier survival analysis, and multivariate Cox proportional hazards modeling we analyzed ...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
ConclusionsCNS-RF is a relevant measure of prognosis in patients who have already achieved a period of remission. Providing an updated estimation of prognosis in the years following diagnosis may improve the survivors’ quality of life and access to credit or insurance.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
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Source: News - Category: American Health Source Type: news
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