Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma

Conclusion: Higher pretreatment RDW levels were demonstrated to be associated with poor clinical outcome in male LSCC patients and might be novel markers for patient stratification in LSCC management. Introduction Laryngeal cancer is one of the most common cancers of the head and neck, of which the estimated crude incidence and mortality rates in China were 1.86/100,000 and 1.01/100,000, respectively (1). This disease has a male predominance with a male-to-female ratio of 20 to 30:1 in China (2). The most commonly observed histological type of laryngeal cancer is laryngeal squamous cell cancer (LSCC), accounting for 95% of cases involving the stratified squamous epithelial lining of the larynx (3, 4). Despite improvements in diagnosis and treatment in the last four decades, there was an absence of a significant change in the 5-year overall survival (OS) rate for larynx cancer patients (5). Several prognostic factors have been identified to predict prognosis in LSCC patients, such as tumor size, histological subtype or grade, vascular invasion, and lymph node metastases. However, the majority of these factors can only be assessed after surgery. Although “omics”-based technology has enhanced our perception of possible risk factors, prognoses and/or responses to treatment biomarkers, the validation of novel molecular biomarkers is associated with high costs, time-consuming procedures, and laboratory efforts. Therefore, a simple, rapid, reliable, and cheap pret...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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CONCLUSIONS In the natural sitting position, a reduction in LL was associated with TK, SVA and PT increased, and there were differences between men and women. The characteristics of spinopelvic alignment in healthy older adults should be considered when planning corrective spinal surgery. PMID: 31981456 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS Our results showed that sarcopenia was significantly and independently associated with cognitive decline and falls, but not associated with hospitalization, in the community-dwelling oldest old. PMID: 31980594 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Testing has confirmed a person who passed through RDU Airport on Thursday was not infected with the deadly coronavirus. The N.C. Division of Public Health said testing done at the Centers for Disease Control in Atlanta came back negative for the virus. The patient was being treated at Duke University Hospital in Durham. The patient had recently been in Wuhan, China, where the spread of the virus originated. The p erson passed through JFK Airport in New York before flying to RDU. NCDHHS officials…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Publication date: April 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 188Author(s): Didem Cetin, Meltem Okan, Erhan Bat, Haluk KulahAbstractDetection of circulating tumor cells (CTCs) from the bloodstream holds great importance to diagnose cancer at early stages. However, CTCs being extremely rare in blood makes them difficult to reach. In this paper, we introduced different surface modification techniques for the enrichment and detection of MCF-7 in microfluidic biosensor applications using gold surface and EpCAM antibody. Mainly, two different mechanisms were employed to immobilize the antibodies; covalent b...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: 25 March 2020Source: Journal of Industrial and Engineering Chemistry, Volume 83Author(s): Xuan Thang Cao, Maheshkumar Prakash Patil, Quoc Thang Phan, Cuong M.Q. Le, Byung-Hyun Ahn, Gun-Do Kim, Kwon Taek LimAbstractThis paper reports a green and direct functionalization of poly(ethylene glycol)-graft-[furfuryl-graft-(poly(styrene-alt-maleic anhydride))] (PEG-PSMF) on the surface of single walled carbon nanotubes (SWCNTs) in aqueous media through Diels-Alder (DA) click reaction. Firstly, novel PEG grafted, furfuryl functionalized copolymers were prepared by RAFT polymerization followed by ring opening react...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Publication date: Available online 25 January 2020Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Yan Li, Shuai Wang, Fang Xiang Song, Li Zhang, Wei Yang, Hong Xia Wang, Qian Lin ChenAbstractMesoporous silica nanoparticles with folic acid (MSN-COOH-Tet-HBP-FA) are able to mediate targeting and have a pH stimulation response character, and therefore have been successfully synthesized as vectors for antitumor drug delivery. The model drug is tetrandrine (Tet). The chemical structure and properties of these NPs were characterized through systematic characterization analyses. Their drug loadi...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9NJ05860E, PaperFan Gao, Fei Wang, Xuan Nie, Ze Zhang, Guang Chen, Lei Xia, Long-Hai Wang, Chang-Hui Wang, Zong-Yao Hao, Wen-Jian Zhang, Chun-Yan Hong, Ye-Zi You Mitochondrial malfunction is considered to be a decisive signal of apoptosis. It would be a promising strategy to target mitochondria in cancer cells to generate reactive oxygen species (ROS) directly... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Publication date: Available online 26 January 2020Source: Regional Science and Urban EconomicsAuthor(s): Fédéric Holm-HadullaAbstractThis paper studies the impact of redistributive fiscal equalization transfers on the choice between a distortionary capital tax and a non-distortionary land tax at the local layer of government. In a standard tax competition model, the paper shows that this impact is ambiguous in that: depending on the motives driving local policy choices, fiscal equalization may either induce a more or a less distortionary tax structure. Using a natural experiment from German municipal finance,...
Source: Regional Science and Urban Economics - Category: Science Source Type: research
Publication date: Available online 25 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Xihan Guo, Xiayu Wu, Juan Ni, Ling Zhang, Jinglun Xue, Xu WangAbstractBulbus Fritillariacirrhosa D. Don (BFC) has been widely used as an herbal medicament for respiratory diseases in China for over 2000 years. The ethnomedicinal effects of BFC have been scientifically verified, nevertheless its toxicity has not been completely studied. Previously, we have reported that the aqueous extract of BFC induces mitotic aberrations and chromosomal instability (CIN) in human colon epithelial NCM460 c...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 25 January 2020Source: Journal of Vascular Surgery: Venous and Lymphatic DisordersAuthor(s): Steven M. Dean, Elizabeth Valenti, Karen Hock, Julie Leffler, Amy Compston, William T. AbrahamAbstractBackgroundLower extremity lymphedema is frequently encountered in the vascular clinic. Established dogma purports that cancer is the most common cause of lower extremity lymphedema in Western countries, whereas chronic venous insufficiency (CVI) is often overlooked as a potential cause. Moreover, lymphedema is typically ascribed to a single cause, yet multiple causes can coexist.MethodsA 3-year re...
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - Category: Surgery Source Type: research
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