21-Gene Recurrence Score Assay Could Not Predict Benefit of Post-mastectomy Radiotherapy in T1-2 N1mic ER-Positive HER2-Negative Breast Cancer
Conclusion: This study showed that the 21-gene RS assay was not able to predict the benefit of PMRT for OS in women with T1-2 N1mic ER-positive HER2-negative breast cancer. However, further prospective larger sample-size trials are warranted to determine if a benefit exists. Introduction According to the latest Global Cancer Statistics 2018, breast cancer is still the most frequent cancer and the leading cause of cancer death among females worldwide (1). It is estimated that there will be about 2.1 million newly diagnosed female breast cancer cases and 627,000 cancer death in 2018 (1). The use of screening tests for breast cancers provides better opportunities for patients to detect disease at an earlier stage and obtain more effective treatment with fewer side effects. As reported by the National Cancer Institute (NCI) in the Surveillance, Epidemiology, and End Results Program (SEER), about 93% of female breast cancers are diagnosed at localized or regional stage1. For early-stage breast cancer patients, three landmark clinical trials have demonstrated that post-mastectomy radiotherapy (PMRT) reduces locoregional recurrences (LRRs) and improves overall survival (OS) in high-risk patients, namely those with pathologically involved axillary nodes or with large tumor size (>5 cm) (2–4). And subsequently, subgroup analysis of DBCG 82 b &c trials (5) and meta-analyses from European Organization for Research on Treatment of Cancer (EORTC) (6) also showed the sam...
A novel approach using deep neural network frameworks shows promise for the diagnosis of basal-cell carcinoma via a smartphone camera.The British Journal of Dermatology
A newly developed model to profile risk for Zika virus emergence provides important information for prevention efforts and resource utilization.Emerging Infectious Diseases
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CONCLUSION: Survival across the two time periods remained stable for oral SCC but showed a significant increase for oropharyngeal SCC, possibly because of improvements in the patients ’ response to radiotherapy, such as intensity-modulated radiation therapy, and the use of more accurate diagnostic imaging approaches.
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ABSTRACT Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. The Brazilian Society of Hepatology (SBH) published in 2015 its first recommendations about the management of HCC. Since then, new data have emerged in the literature, prompting the governing board of SBH to sponsor a single-topic meeting in August 2018 in S ão Paulo. All the invited experts were asked to make a systematic review of the literature reviewing the management of HCC in subjects with cirrhosis. After the meeting, all panelists gathered together for the discussion of the topics and the elaboration o...
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