Establishment and Verification of a Bagged-Trees-Based Model for Prediction of Sentinel Lymph Node Metastasis for Early Breast Cancer Patients

Conclusions: Our model is more reliable and stable to assist doctors predict the SLN metastasis in breast cancer patients before operation. Introduction The incidence of breast cancer is the first in female malignant tumors, in which the highest incidence of breast cancer has been reported in Europe and the United States, however, in recent years, the incidence of breast cancer in China has annually increased (1, 2). Based on surgery as an important step in the treatment of breast cancer, in recent years, different individuals have never stopped exploration of a novel and optimum approach. Besides, NSABP-04, ASCOG-Z0011, and other tests have shown that for breast cancer patients with T1-T2 stage and clinical negative lymph node (cN0) during breast preservation surgery and total breast radiotherapy, axillary lymph node dissection (ALND) does not contain great benefits to the long-term survival of patients. As a result, sentinel lymph node biopsy (SLNB) has been gradually replaced with conventional ALND as a routine surgical method for early breast cancer patients (3–7). However, SLNB, as an invasive operation, leads to some postoperative complications. Although the corresponding incidence rate is lower than ALND, however, those complications should not be ignored. Moreover, SLNB has a high degree of professional requirement for physicians, and the richness of physician's experience directly affects the evaluation of the pathological status of sentinel lym...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Publication date: Available online 20 October 2019Source: European Journal of RadiologyAuthor(s): Chuqian Lei, Wei Wei, Zhenyu Liu, Qianqian Xiong, Ciqiu Yang, Mei Yang, Liulu Zhang, Teng Zhu, Xiaosheng Zhuang, Chunling Liu, Zaiyi Liu, Jie Tian, Kun WangAbstractPurposeWe developed and validated a radiomic model based on mammography and assessed its value for predicting the pathological diagnosis of Breast Imaging Reporting and Data System (BI-RADS) category 4 calcifications.Materials and MethodsPatients with a total of 212 eligible calcifications were recruited (159 cases in the primary cohort and 53 cases in the validatio...
Source: European Journal of Radiology - Category: Radiology Source Type: research
Publication date: Available online 20 October 2019Source: Journal of Vocational BehaviorAuthor(s): Emmanuelle Vignoli, Nathalie Prudhomme, Katia Terriot, Valérie Cohen-Scali, Caroline Arnoux-Nicolas, Jean-Luc Bernaud, Noëlle LallemandAbstractThe first aim of this study was to validate a French version of the Decent Work Scale (DWS) proposed by Duffy, Allan, Blustein, England, Douglass, Ferreira, and Santos (2017). Our second aim was to gain insight into French people's representations of decent work using a qualitative approach. A representative sample of 300 French employees completed the DWS, as well as measu...
Source: Journal of Vocational Behavior - Category: Psychiatry & Psychology Source Type: research
ConclusionsThe relevance of SPARC expression in pancreato-biliary carcinomas though may still be important for therapeutic decision making, it is not responsible for peritumoral stromal desmoplasia in these tumors and it does not have any significant prognostic implication.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
We present for the first time a case of MFS of the breast induced by radiotherapy.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Objectives: To determine the feasibility and impact of real-time anti-factor Xa (aFXa) level monitoring and enoxaparin dose adjustment in orthopaedic trauma. To examine the adequacy of standard fixed-dose enoxaparin chemoprophylaxis and to examine whether patient-specific factors influence enoxaparin metabolism. Design: Prospective cohort. Setting: Academic Level-I trauma center. Patients: Postoperative adult orthopaedic trauma patients undergoing acute fracture or nonunion surgery of the pelvis, acetabulum, or lower extremity placed on 30 mg of enoxaparin twice daily. Intervention: Peak steady-state aFXa lev...
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
This study explored the association between serum vitamin D levels and urinary tract infections in pregnant women.Study designIn this case control study, 187 participants including, 97 pregnant women diagnosed as a symptomatic UTI (case group) and 90 matched healthy pregnant women (control group) were consecutively enrolled from prenatal care clinic of Imam Reza Hospital in Urmia, North West of Iran. The two groups were matched for trimester and parity, and sexual intercourse. Blood samples were collected from both groups. Chemiluminescent immunoassay (CLIA) was used to evaluate the serum vitamin D levels. We used a binary...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Publication date: Available online 20 October 2019Source: The LancetAuthor(s): Daniel I Sessler, Lijian Pei, Yuguang Huang, Edith Fleischmann, Peter Marhofer, Andrea Kurz, Douglas B Mayers, Tanja A Meyer-Treschan, Martin Grady, Ern Yu Tan, Sabry Ayad, Edward J Mascha, Donal J Buggy, Gang Tan, Zhiyong Zhang, Helen Keane, Maurice Stokes, Oliver Zotti, Michael Gnant, Silvia Perez-ProttoSummaryBackgroundThree perioperative factors impair host defence against recurrence during cancer surgery: the surgical stress response, use of volatile anaesthetic, and opioids for analgesia. All factors are ameliorated by regional anaesthesia...
Source: The Lancet - Category: General Medicine Source Type: research
OBJECTIVE: To perform a descriptive analysis of preterm premature rupture of membranes (PPROM) cases attended in a tertiary hospital. METHOD: Retrospective analysis of medical records and laboratory tests of patients admitted to a Brazilian tertiary hospital between 2006 and 2011, with a confirmed diagnosis of PPROM and gestational age (GA) at delivery
Source: Clinics - Category: General Medicine Source Type: research
Authors: Partido BB, Colón M Abstract Purpose: Research is integral to dental hygiene practice, graduate education, and the advancement of the dental hygiene profession. The purpose of this study was to identify the motivations and challenges toward participation in research activities as perceived by undergraduate dental hygiene students.Methods: A nonprobability sample of undergraduate dental hygiene students from across the United States was used for this cross-sectional, electronic survey. Inclusion criteria were students entering their final year of their dental hygiene education program. Descriptive an...
Source: Journal of Dental Hygiene - Category: Dentistry Tags: J Dent Hyg Source Type: research
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