Mesenchymal Stem Cells Improve Rheumatoid Arthritis Progression by Controlling Memory T Cell Response

Conclusion Memory T cells have been largely studied for their pivotal role in the pathogenesis of auto-immune disease such as RA. Although pro-inflammatory memory T cells-exhibit detrimental effect in RA, their potential plasticity offers an approach yet to be explored in order to better control RA progression. In this context, MSCs, potent immunosuppressive cells that are able to inhibit pro-inflammatory T cell proliferation and functions while inducing the generation of regulatory T cells, represent a strong candidate to choose for RA treatment. Thus, deciphering the basis of the crosstalk between MSCs and pathogenic memory T cells in RA will pave the way for developing novel and potent strategies to successfully improve MSC-based therapies. Author Contributions NL-C, RC-L, FD, RE-V, and PL-C. wrote the manuscript with the input of MP-M, MT, SB, MW, and FE. Funding This work was supported by Fondo Nacional de Desarrollo Científico y Tecnológico 408 (FONDECYT) Iniciación 11160929, Inserm, the University of Montpellier and the Société Française de Rhumatologie (SFR). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References 1. Le Blanc K, Mougiakakos D. Multipotent mesenchymal stromal cells and the innate immune system. Nat Rev Immunol. (2012) 12:383–96. ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research