Aggregatibacter actinomycetemcomitans (Aa) Under the Radar: Myths and Misunderstandings of Aa and Its Role in Aggressive Periodontitis
Conclusions Current data indicates that Aa can colonize tooth surfaces above the gum-line and that this is an early event. In the section below we will describe how Aa can compete for nutritional elements with a multitude of rival bacteria in order to survive. Misconception 2: Nutritional Fastidious Nature of Aa Clinical Aa has been characterized as a fastidious microbe that requires CO2, serum, and specific carbohydrates such as glucose for its growth (34). It has been reported that Aa has a mandatory requirement for 5% CO2 for primary isolation, and that its growth is purported to be boosted by addition of serum (34). The difficult recovery of the microbe from potentially diseased sites throughout the body has been attributed to Aa's fastidious nature and its slow and inconsistent growth after initial isolation. These characteristics have suggested that the organism is difficult to isolate from human sites and difficult to grow in the laboratory. These features coupled with the aggregative nature of the microbe when grown in the laboratory has made quantitative assessment of the microbe problematic. Further, these features have discouraged a more intense investigation of the genetic traits of Aa (13). More recently genetic methodologies have made it easier to do quantitative assessment of the microbe from individual periodontal sites of interest. Molecular In 2007, Brown and Whiteley demonstrated that Aa preferentially metabolizes lactate over other more readi...
Publication date: Available online 27 March 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): He Wang, Yao Wang, Qi-Wen Yang, Yu-Xing Ni, Li-Kai Lin, Yan-Ping Luo, Zi-Yong Sun, Min Li, Wen-Juan Wu, Qiang-Qiang Zhang, Dan-Hong Su, Hua Yu, Mei Kang, He-Ping Xu, Wei Liu, Qing Yang, Cui Jian, Li-Na Guo, Wen-Hang Yang, Meng Xiao
Publication date: Available online 26 March 2020Source: Physics Letters BAuthor(s): W. Scandale, G. Arduini, F. Cerutti, M. Garattini, S. Gilardoni, R. Losito, A. Masi, D. Mirarchi, S. Montesano, S. Redaelli, R. Rossi, G. Smirnov, D. Breton, L. Burmistrov, V. Chaumat, S. Dubos, J. Maalmi, V. Puill, A. Stocchi, E. Bagli
Optical scanning holography requires interference optics, which separates a laser beam into two paths and recombines the two path beams ...
Authors: Cron RQ, Chatham WW Abstract The novel coronavirus (SARS-CoV-2) pandemic has spread rapidly throughout the planet. It is believed to have originated in the Wuhan province of China, but this highly contagious respiratory virus has spread to over 140 countries on 6 continents as of mid-March 2020 according to the World Health Organization (WHO). Worldwide, there have been over 164,000 cases identified and over 6,500 deaths attributed to the viral infection. As of March 15, 2020, there are over 3,700 confirmed cases and 68 deaths ascribed to Covid-19 (the disease caused by SARS-CoV-2) in the United States [ht...
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Publication date: Available online 26 March 2020Source: Marine ChemistryAuthor(s): Ruei-Feng Shiu, Meng-Hsuen Chiu, Carlos I. Vazquez, Yi-Yen Tsai, Andre Le, Agnes Kagiri, Chen Xu, Manoj Kamalanathan, Hernando Bacosa, Shawn Doyle, Jason Sylvan, Peter H. Santschi, Antonietta Quigg, Wei-Chun Chin
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