Intestinal Epithelial Cells-Derived Hypoxia-Inducible Factor-1 α Is Essential for the Homeostasis of Intestinal Intraepithelial Lymphocytes

Intestinal Epithelial Cells-Derived Hypoxia-Inducible Factor-1α Is Essential for the Homeostasis of Intestinal Intraepithelial Lymphocytes Lihua Sun1, Teming Li1, Hanlin Tang1, Kun Yu1, Yuanhang Ma1, Min Yu1, Yuan Qiu1, Pengyuan Xu2, Weidong Xiao1* and Hua Yang1* 1Department of General Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China 2Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, China Hif-1α is a master regulator which involved in the transcriptional regulation of anti-inflammatory or cellular responding to hypoxia. Previous work shows that the absence of Hif-1α results in the destruction of intestinal epithelial cell (IEC) and abnormalities of intestinal barrier function. However, we know very little about other functions of Hif-1α on intestinal intraepithelial lymphocyte (IEL). Therefore, we generated a transgenic mouse (Hif1-αΔIEC mice), which was knocked out Hif1-α specifically in IECs, to study the effect of Hif1-α on IEL. IELs were isolated from the small intestine and colon of mice, respectively, and examined by flow cytometry and quantitative real-time PCR. All the cytokines expression was detected by quantitative real-time PCR. The NSAID enteropathy was induced by gavaged with 5 mg/kg indomethacin and the experimental colitis was induced by administration of 2.5% DSS. We found that the number of IELs is increased in H...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

Authors: Turan AS, Ultee G, Van Geenen EJM, Siersema PD Abstract INTRODUCTION: The most commonly used treatment for advanced colorectal adenomas is endoscopic mucosal resection (EMR). The increased number of EMRs since the introduction of the screening program for colorectal cancer has resulted in an increase in EMR-related complications. This review summarizes the current knowledge for the use of clips for the treatment and prevention of complications after EMR. Areas covered: The historical development of clips is summarized and their properties are evaluated. An overview is presented of the evidence for therapeu...
Source: Expert Review of Medical Devices - Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research
Phys. Chem. Chem. Phys., 2019, Accepted Manuscript DOI: 10.1039/C9CP01306G, PaperJia Liu, Zhen Wang, Zirui Wang, Jinwan Song, Guangshi Li, Qian Xu, Jinglin You, Hongwei Cheng, Xionggang Lu Sodium Orthosilicate was synthesized by a wet chemical method and the further calcination at 600 °C. The mixtures of Na4SiO4 and alkali (Li/Na/K) carbonates were prepared by a mechanically mixing... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
J. Mater. Chem. A, 2019, Advance Article DOI: 10.1039/C9TA03797G, PaperKangyu Zou, Peng Cai, Cheng Liu, Jiayang Li, Xu Gao, Laiqiang Xu, Guoqiang Zou, Hongshuai Hou, Zuming Liu, Xiaobo Ji A kinetically well-matched sodium-ion capacitor was constructed using an anode displaying strong pseudocapacitive storage behavior. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC01506J, CommunicationYuan Ma, Quanbing Mou, Lijuan Zhu, Yue Su, Xin Jin, Jing Feng, Deyue Yan, Xinyuan Zhu, Chuan Zhang Polygemcitabine nanogels assembled from DNA-like polygemcitabine undergo rapid intracellular degradation to generate active gemcitabine derivatives for enhanced cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
AbstractObjectiveTo evaluate factors associated with use of patient navigation in a prostate cancer population and identify whether navigation is associated with prolonged  time to care. Cancer patient navigation has been shown to improve access to cancer screening, diagnosis, and treatment, but little is known about patient navigation in prostate cancer care.MethodsAll men diagnosed with localized prostate cancer between 2009 and 2015 were abstracted from the MaineHealth  multi-specialty tumor registry. Regression analyses controlling for patient-, disease-, and system-level factors evaluated characteristics ass...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionIn conclusion, this study illustrates that the application and benefits of HS on reducing GI rectal dose endpoints and toxicities during prostate cancer RT can be reliably replicated in a community setting similar to centres participating in the randomised trial under high quality assurance trial monitoring.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionThere is a need to enhance a constant patient –HCP dialogue, and both groups need to make a conscious effort in that direction. This would help in increasing patients’ awareness of risks, having better treatment choice and acceptance, and reducing side-effects.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Management of severe elbow arthritis in young or active patients presents a challenging problem. Interposition arthroplasty is a useful salvage procedure for these patients but has a significant failure rate associated with postoperative instability. Previous studies have sought to preserve the integrity of the medial elbow ligament complex to decrease postoperative instability and the need for external fixation. Our lateral epicondylar osteotomy technique preserves the native lateral elbow ligament complex. Potential advantages include bone-to-bone healing of the osteotomy, decreased postoperative instability, and the dec...
Source: Techniques in Hand and Upper Extremity Surgery - Category: Surgery Tags: Techniques Source Type: research
The first toe-to-hand transplantation was done in 1898 by Nicoladoni. It was a staged procedure and the toe flap was based on a pedicle. With advancement of optical instruments and microsurgeons’ skills in 1964 the first microvascular toe-to-hand transplantation on a rhesus monkey was done. The technique’s development has not stopped, many authors have modified it to achieve better outcomes for both traumatic and congenital hand defects. The most commonly used toes for transplantation are first, second, and second to third toe block. Well described plantar and dorsal vascular systems for first web space vessels...
Source: Techniques in Hand and Upper Extremity Surgery - Category: Surgery Tags: Techniques Source Type: research
We report good clinical outcomes postoperative, with intact range of motion and no surgical complication at the 6-month follow-up visit. The patient has ongoing physical therapy to reduce any residual strength deficits.
Source: Techniques in Hand and Upper Extremity Surgery - Category: Surgery Tags: Techniques Source Type: research
More News: Academia | Allergy & Immunology | Arthritis | Belgium Health | Cancer | Cancer & Oncology | Cancer Therapy | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Cervical Cancer | Chemistry | China Health | Chronic Pain | Colon Cancer | Colorectal Cancer | Epithelial Cancer | Gastroenterology | Gastroschisis Repair | Genetics | Germany Health | Grants | Heart | Ibuprofen | Indomethacin | Infectious Diseases | Inflammatory Bowel Disease | Japan Health | Jordan Health | Laboratory Medicine | Medical Ethics | Middle East Health | Nutrition | Pain | Parenteral Nutrition | Physiology | Reproduction Medicine | Rheumatology | Science | Sodium | Statistics | Students | Study | Surgery | Toxicology | Transplants | Universities & Medical Training | Vitamin D | Vitamin D Deficiency | Vitamins | Weight Loss