Baclofen but Not Diazepam Alleviates Alcohol-Seeking Behavior and Hypothalamic –Pituitary–Adrenal Axis Dysfunction in Stressed Withdrawn Mice

In conclusion, this study evidences that a pre-treatment with baclofen but not with diazepam during the withdrawal phase normalized, even after a long period of abstinence, the HPA axis response to stress, which contributes to the long-term preventing effects of this compound on alcohol-seeking behavior.IntroductionThere is substantial evidence that cognitive and neurobiological alterations are either dramatically enhanced or gradually developed after alcohol withdrawal (1–4). One of the main disturbances associated with alcohol withdrawal involves a dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, which accounts for excessive glucocorticoid (GC) release (5). Thus, evidence in humans (6–8) and rodents (9–11) has shown that alcohol withdrawal markedly affects plasma GC levels. Moreover, studies in rodents have evidenced brain regional GC disturbances after long alcohol withdrawal periods (12), which account for protracted cognitive dysfunction (13, 14).The relationships between the HPA axis activity, craving, and alcohol intake during early abstinence have been well documented (15, 16). Clinical and experimental studies pointed out how corticosterone and stress interact with the brain reward system and contribute to alcohol reinforcing effects (17, 18) and relapse to alcohol-seeking behavior (15). Therefore, reducing or suppressing GC dysregulations in alcohol-withdrawn mice can prevent relapse to alcohol-seeking behavior.A way to a...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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Ketamine was once used mainly as an anesthetic on battlefields and in operating rooms. Now this medication is gaining ground as a promising treatment for some cases of major depression, which is the leading cause of disability worldwide. In the US, recent estimates show 16 million adults had an episode of major depression in the course of a year. Suicide rates rose substantially between 1999 and 2016, increasing by more than 30% in 25 states. Because of its rapid action, ketamine could have a role to play in helping to prevent suicide. Why is ketamine exciting for treating depression? If a person responds to ketamine, it c...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Anxiety and Depression Health Health trends Mental Health Source Type: blogs
You're reading These 5 Mental Health Tools Will Help You Cope with Any Difficult Situation, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Though it may be a surprise for some, mental health problems are commonplace. According to the National Alliance on Mental Illness, nearly 44 million American adults deal with mental health symptoms on an annual basis. That’s nearly 20% of the country’s adult population. Thankfully, similar to physical conditions like joint pain or eczema, mental health problems can be tr...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: confidence depression featured happiness health and fitness meditation motivation psychology self confidence self improvement Uncategorized affirmations best self-improvement blogs how to be successful mental health pickthebr Source Type: blogs
Getting Clean from Opioids Making the decision to finally get clean from opioids is the most important step in your life. Chances are, you have tried to control your use but are unable to withdrawal from opioids. This is completely normal because one of the major signs of addiction is the inability to control use. While this can be very frustrating and has likely caused a lot of negative consequences in your life, it is important to know that you’re not a failure. You are chemically dependent on a substance that is difficult to quit by yourself. In addition, you are certainly not alone. According to the National Inst...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Recovery Addiction to Pharmaceuticals Detox Resources for Alcohol and Drugs/Opiates Drug Treatment Substance Abuse medical detox medicated-assisted detox opiate abuse opiate addiction opioid opioids withdrawal Source Type: blogs
AbstractResearch suggests drinking motives and drinking context mediate the relation between social anxiety and alcohol problems. Study 1 examined coping with anxiety motives (CAM) and coping with depression motives (CDM) as distinct mediators in a self-report cross-sectional study of 263 undergraduate drinkers. CDM mediated the relation between social avoidance and alcohol problems (indirect effect  = 0.07). Study 2 included drinking contexts and motives as mediators in a single model and included an additional coping with social anxiety drinking motive (CSAM) mediator in a self-report cross-sectional study ...
Source: International Journal of Mental Health and Addiction - Category: Addiction Source Type: research
What is Detox from Methadone Like? Methadone is a long-acting opioid medication. It was originally designed to help people in treatment struggling with addiction to opioids, such as heroin. It is used to slowly wean people off of heroin and opioids so that they do not experience sudden and unpleasant withdrawal symptoms. However, methadone in and of itself has addictive properties as well, as it is a Schedule II controlled substance. This means it has a high potential for abuse and can produce physiological dependence in users. Many people who were once addicted to heroin may become addicted to methadone for these reasons....
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction Recovery Addiction to Pharmaceuticals Addiction Treatment and Program Resources Detox Resources for Alcohol and Drugs/Opiates drug detox medical detox medicated-assisted detox methadone opiate abuse opiate addiction Source Type: blogs
Gyöngyi Kökönyei1,2,3*, Natália Kocsel1,2,3,4, Orsolya Király1, Mark D. Griffiths5, Attila Galambos1,2,4, Anna Magi1,4, Borbála Paksi6 and Zsolt Demetrovics11 Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary2SE-NAP2 Genetic Brain Imaging Migraine Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary3Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary4Doctoral School of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary5Psychology Department, Not...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Detox from Benzodiazepines Benzodiazepines are highly addictive medications. They are used to help treat anxiety, sleep issues, and even seizures. They work to calm the body and can be a great, helpful tool for many people when used as prescribed. There are many different types of Benzodiazepines, as they differ in strength and onset time. Some Benzodiazepines, such as Librium, is used to help treat symptoms associated with alcohol withdrawal. Detox from Benzodiazepines can be difficult, but it is possible. The names that people know most commonly know Benzodiazepines as include: Xanax Valium Ativan Klonopin They are onl...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Detox Resources for Alcohol and Drugs/Opiates Substance Abuse benzo benzodiazepines medical detox Source Type: blogs
Conclusion: Fun seeking on the BAS and frustration intolerance should be considered as targets in prevention and intervention programs for IA among adolescents with ADHD.IntroductionThe negative effects of internet addiction (IA) have become a concern in the past decades. IA is characterized by persistent internet use despite negative consequences, loss of control, preoccupation with internet use, increasing amounts of time spent online, and withdrawal symptoms (1). Internet gaming disorders are listed in the “Conditions for Further Study” section in the Fifth Edition of Diagnostic and Statistical Manual of Men...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
 Even if we live with mental illness, ourselves, we can be frustrated when we don’t know how to help a friend or family member who’s dealing with it. We may find that coping skills that work for us may not work for someone else. Medications that work for us may not work for the other person. In this episode, Gabe and Michelle discuss how to help friends with mental illness, including the help available through caregivers, medication, and more.   SUBSCRIBE &REVIEW “And I wonder to myself, ‘Why do you tolerate this s**t?’” – Gabe Howard   Highlights From &lsq...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Caregivers Depression Friends Source Type: blogs
What is Clonidine? Originally developed as a nasal decongestant, Clonidine has been found to work very well for patients experiencing withdrawal symptoms from opiates. According to the JamaNetwork, Clonidine produces a rapid and statistically significant decrease in opiate withdrawal signs and symptoms. Clonidine administration for 14 days enabled all patients to be successfully detoxified from chronic opiate administration. In all patients studied, clonidine was a safe and effective non-opiate treatment of opiate withdrawal that suppressed the effect, signs, and symptoms of opiate withdrawal. Withdrawal Symptoms When some...
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