5-ALA fluorescence –guided surgery in pediatric brain tumors—a systematic review
Conclusion5-ALA could play a role in resection of pediatric brain tumors. However, further prospective clinical trials are needed.
Publication date: 25 November 2019Source: Journal of Industrial and Engineering Chemistry, Volume 79Author(s): Ramesh Duwa, Fakhrossadat Emami, Sooyeun Lee, Jee-Heon Jeong, Simmyung YookAbstractGlioblastoma multiforme (GBM) is the most aggressive, malignant brain tumor found in adults, and has a short median survival time (MST). GBM is a heterogeneous group of brain tumors, is highly prone to develop resistance and likely to recur. In the context of GBM, the delivery of anti-cancer drugs is challenging because the blood brain barrier (BBB) restricts the passage of small molecules. Currently, nanomedicines based on liposome...
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Immaculada Mart ínez-Rovira, Olivier Seksek, Ibraheem Yousef The inclusion of nanoparticles (NP) in radiotherapy has shown to increase the damaging effect on tumor cells. However, the mechanisms of action of NP combined with radiotherapy, and the influence... The content of this RSS Feed (c) The Royal Society of Chemistry
Conditions: Glioma, Malignant; Gliosarcoma; Astrocytoma of Brain Intervention: Drug: Intranasal Modified Temozolomide Sponsor: Center Trials & Treatment Europe Not yet recruiting
AbstractObjective5-Aminolevulinic acid (5-ALA) –guided resection of gliomas in adults enables better delineation between tumor and normal brain, allowing improved resection and improved patients’ outcome. Recently, several reports were published regarding 5-ALA for resection of pediatric brain tumors. The aim of the study was to determine th e intracellular fluorescence of protoporphyrin IX (PPIX) in pediatric brain tumors by hyperspectral imaging and to compare it with visually observed intraoperative fluorescence.Methods5-ALA was administered orally 4 h prior to surgery. During tumor resection, the surg...
ConclusionH3 K27M mutations are frequent in adult midline gliomas and have a prognostic role similar to H3 K27M wild-type high-grade tumors.
CONCLUSION: H3 K27M mutations are frequent in adult midline gliomas and have a prognostic role similar to H3 K27M wild-type high-grade tumors. PMID: 30610375 [PubMed - as supplied by publisher]
Conclusion: Compared to PFT patients treated with surgery alone, PFT patients treated with chemo-radiotherapy showed lower hippocampal volumes and altered hippocampal growth trajectory. Serial quantitative MRI measures of brain may provide a neuroanatomical substrate for assessing functional impact on normal brain function following treatment of posterior fossa tumours. PMID: 28748803 [PubMed - as supplied by publisher]
Pediatric brain tumors are the leading cause of death from solid tumors in childhood. The most common posterior fossa tumors in children are medulloblastoma, atypical teratoid/rhabdoid tumor, cerebellar pilocytic astrocytoma, ependymoma, and brainstem glioma. Location, and imaging findings on computed tomography (CT) and conventional MR (cMR) imaging may provide important clues to the most likely diagnosis. Moreover, information obtained from advanced MR imaging techniques increase diagnostic confidence and help distinguish between different histologic tumor types. Here we discuss the most common posterior fossa tumors in ...
ConclusionsWe identify common features and individual differences in the systemic immune profiles of children with brain tumors. Overall, patients with MB displayed a uniform cytokine profile, whereas other tumor diagnoses did not predict systemic immunological status in single patients. Future characterization and monitoring of systemic immune responses in children with brain tumors will have important implications for the development and implementation of immunotherapy.
The posterior fossa is the site of many types of tumors, and brain metastases are the most common malignancies in that location among adults. Other brain tumors, such as ependymomas, medulloblastomas and juvenile pilocytic astrocytomas, mostly occur during childhood and are relatively rare in the adult population. The majority of primary malignant brain tumors, such as gliomas and lymphomas, tend to be located in the supratentorial compartment.